The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds
Sign Up to like & getrecommendations! Published in 2018 at "Heliyon"
DOI: 10.1016/j.heliyon.2018.e00959
Abstract: An mRNA gene therapy represents a potentially promising therapeutic for curing inflammatory diseases. The transient nature of the gene expression of mRNA would be expected to be beneficial for avoiding undesired side effects. Since the… read more here.
Keywords: acid scaffolds; delivery mrna; oleic acid; colon ... See more keywords
Engineering Lipid Nanoparticles for Enhanced Intracellular Delivery of mRNA through Inhalation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c05647
Abstract: Despite lipid nanoparticles' (LNPs) success in the effective and safe delivery of mRNA vaccines, an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs tend to disintegrate due to shear stress during aerosolization, leading to… read more here.
Keywords: lipid nanoparticles; endosomal escape; delivery mrna; delivery ... See more keywords
Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40147-y
Abstract: Intracellular delivery of functional macromolecules, such as DNA and RNA, across the cell membrane and into the cytosol, is a critical process in both biology and medicine. Herein, we develop and use microfluidic chips containing… read more here.
Keywords: vortex shedding; delivery mrna; delivery; intracellular delivery ... See more keywords
Hybrid nanovaccine for the co-delivery of the mRNA antigen and adjuvant.
Sign Up to like & getrecommendations! Published in 2019 at "Nanoscale"
DOI: 10.1039/c9nr05475h
Abstract: For efficient cancer vaccines, the antitumor function largely relies on cytotoxic T cells, whose activation can be effectively induced via antigen-encoding mRNA, making mRNA-based cancer vaccines an attractive approach for personalized cancer therapy. While the… read more here.
Keywords: delivery mrna; delivery; antigen; hybrid nanovaccine ... See more keywords
Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207841119
Abstract: Significance Current messenger RNA (mRNA) vaccines in the clinic were reported to induce side effects in the liver, such as reversible hepatic damages and T cell–dominant immune-mediated hepatitis, which might be caused by the undesired… read more here.
Keywords: vaccine elicits; node targeting; mrna; delivery mrna ... See more keywords
Safe and Effective Delivery of mRNA Using Modified PEI-Based Lipopolymers
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020410
Abstract: Chemically modified mRNA (modRNA) has proven to be a versatile tool for the treatment of various cancers and infectious diseases due to recent technological advancements. However, a safe and effective delivery system to overcome the… read more here.
Keywords: delivery mrna; effective delivery; safe effective; delivery ... See more keywords