Advances in peptide-mediated cytosolic delivery of proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.02.003
Abstract: The number of protein-based drugs is exponentially increasing. However, development of protein therapeutics against intracellular targets is hampered by the lack of efficient cytosolic delivery strategies. In recent years, the use of cell-penetrating peptides has… read more here.
Keywords: cytosolic delivery; peptide mediated; delivery proteins; delivery ... See more keywords
Noncompetitive Active Transport Exploiting Intestinal Transferrin Receptors for Oral Delivery of Proteins by Tunable Nanoplatform
Sign Up to like & getrecommendations! Published in 2017 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.7b00035
Abstract: Here we present a “thinking-outside-the-box”, tunable nanoplatform for oral delivery of proteins using insulin as a model protein. These nanosystems offer noncompetitive active transport exploiting transferrin receptors present in the intestine and permit tailored release… read more here.
Keywords: tunable nanoplatform; oral delivery; delivery proteins; delivery ... See more keywords
Direct Cytosolic Delivery of Proteins Through Co-Engineering of Proteins and Polymeric Delivery Vehicles.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12759
Abstract: Nanocarrier-mediated protein delivery is a promising strategy for fundamental research and therapeutic applications. However, the efficacy of current platforms for delivery into cells is limited by endosomal entrapment of delivered protein cargo, with concomitantly inefficient… read more here.
Keywords: cytosolic delivery; proteins engineering; delivery proteins; delivery ... See more keywords
A ligand-based system for receptor-specific delivery of proteins
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55797-1
Abstract: Gene delivery using vector or viral-based methods is often limited by technical and safety barriers. A promising alternative that circumvents these shortcomings is the direct delivery of proteins into cells. Here we introduce a non-viral,… read more here.
Keywords: ligand based; based system; system; delivery proteins ... See more keywords