Foliar Delivery of siRNA Particles for Treating Viral Infections in Agricultural Grapevines.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced functional materials"
DOI: 10.1002/adfm.202101003
Abstract: Grapevine leafroll disease (GLD) is a globally spreading viral infection that causes major economic losses by reducing crop yield, plant longevity and berry quality, with no effective treatment. Grapevine leafroll associated virus-3 (GLRaV-3) is the… read more here.
Keywords: delivery sirna; sirna particles; foliar delivery; particles treating ... See more keywords
Delivery of siRNA using hyaluronic acid‐guided nanoparticles for downregulation of CXCR4
Sign Up to like & getrecommendations! Published in 2023 at "Biopolymers"
DOI: 10.1002/bip.23535
Abstract: In this study, effective transport of small interfering RNAs (siRNAs) via hyaluronic acid (HA) receptor was carried out with biodegradable HA and low‐molecular weight polyethyleneimine (PEI)‐based transport systems. Gold nanoparticles (AuNPs) capable of giving photothermal… read more here.
Keywords: sirna using; delivery sirna; sirna; cxcr4 ... See more keywords
Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Hematology"
DOI: 10.1007/s00277-019-03713-y
Abstract: Efficient and safe delivery of siRNA in vivo is the biggest roadblock to clinical translation of RNA interference (RNAi)-based therapeutics. To date, lipid nanoparticles (LNPs) have shown efficient delivery of siRNA to the liver; however,… read more here.
Keywords: oncogene; cml; vivo; delivery sirna ... See more keywords
Sustained delivery of siRNA/mesoporous silica nanoparticle complexes from nanofiber scaffolds for long-term gene silencing.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.05.054
Abstract: A low toxicity and efficient delivery system is needed to deliver small interfering RNAs (siRNA) in vitro and in vivo. The use of mesoporous silica nanoparticles (MSN) is becoming increasingly common due to its biocompatibility,… read more here.
Keywords: sirna msn; delivery sirna; long term; delivery ... See more keywords
Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.7b05430
Abstract: RNA interference (RNAi) technology has shown great promise for the treatment of cancer and other genetic disorders. Despite the efforts to increase the target tissue distribution, the safe and effective delivery of siRNA to the… read more here.
Keywords: delivery sirna; lipid based; delivery; based liquid ... See more keywords
Stabilization and Movable Ligand-Modification by Folate-Appended Polyrotaxanes for Systemic Delivery of siRNA Polyplex.
Sign Up to like & getrecommendations! Published in 2022 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00462
Abstract: To achieve a systemic targeted delivery of siRNA using polymeric carriers, there is a dilemma between ligand modification and stabilization of the polyplex. Namely, ligand modification often leads to destabilization of the polyplex in the… read more here.
Keywords: sirna; ligand modification; polyplex; delivery sirna ... See more keywords
Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13032-9
Abstract: Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle, and it typically presents with sensorineural hearing loss. The genomic landscape of schwannoma is complex and many of the molecules implicated in VS… read more here.
Keywords: tnf; delivery sirna; delivery; tumor penetrating ... See more keywords
Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/d0bm01497d
Abstract: Bovine milk-derived exosomes have recently emerged as a promising nano-vehicle for the encapsulation and delivery of macromolecular biotherapeutics. Here we engineer high purity bovine milk exosomes (mExo) with modular surface tunability for oral delivery of… read more here.
Keywords: oral delivery; delivery; milk exosomes; delivery sirna ... See more keywords
Nano-formulations for bone-specific delivery of siRNA for CrkII silencing-induced regulation of bone formation and resorption to maximize therapeutic potential for bone-related diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm02038f
Abstract: CrkII, a member of the adaptor protein family, is known to participate in bone homeostasis via the regulation of osteoclasts and osteoblasts. Therefore, silencing CrkII would beneficially impact the bone microenvironment. In this study, CrkII… read more here.
Keywords: specific delivery; bone specific; bone; liposome sicrkii ... See more keywords
Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Bioengineering"
DOI: 10.3390/bioengineering7030091
Abstract: Prostate cancer (PCa) accounts for a high number of deaths in males with no available curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to the lack of symptoms in the early… read more here.
Keywords: delivery sirna; delivery; prostate cancer; pca ... See more keywords
Co-Delivery of siRNA and Chemotherapeutic Drug Using 2C5 Antibody-Targeted Dendrimer-Based Mixed Micelles for Multidrug Resistant Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071470
Abstract: Multidrug resistance (MDR) observed in tumors significantly hinders the efficacy of chemotherapy. Downregulation of efflux proteins, such as P-glycoprotein (P-gp), using small interfering RNA (siRNA) can be an effective way to minimize the resistance in… read more here.
Keywords: dendrimer; delivery sirna; sirna chemotherapeutic; drug ... See more keywords