Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c01501
Abstract: Mutated RAS proteins are potent oncogenic drivers and have long been considered "undruggable". While RAS-targeting therapies have recently shown promise, there remains a clinical need for RAS inhibitors with more diverse targets. Small proteins represent… read more here.
Keywords: nanoparticle delivery; small proteins; lipid nanoparticle; delivery small ... See more keywords
Optimisation of a Microfluidic Method for the Delivery of a Small Peptide
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13091505
Abstract: Peptides hold promise as therapeutics, as they have high bioactivity and specificity, good aqueous solubility, and low toxicity. However, they typically suffer from short circulation half-lives in the body. To address this issue, here, we… read more here.
Keywords: microscopy; method delivery; microfluidic method; optimisation microfluidic ... See more keywords