Tumor-targeted delivery of a STING agonist improves cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214278119
Abstract: Significance The cGAS-STING pathway plays a key role in antitumor immunity. Several STING agonists have shown antitumor efficacy in preclinical studies and are under clinical development. However, systemic administration of STING agonists may have adverse… read more here.
Keywords: sting agonist; tumor targeted; agonist improves; delivery sting ... See more keywords
Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
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DOI: 10.1158/1078-0432.ccr-21-1914
Abstract: Purpose: Activation of STING (stimulator of interferon genes) can trigger a robust, innate antitumor immune response in immunologically “cold” tumors such as glioblastoma. Patients and Methods: A small-molecule STING agonist, IACS-8779, was stereotactically administered using… read more here.
Keywords: results clinical; sting agonist; intratumoral delivery; delivery sting ... See more keywords