Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.113927
Abstract: In recent years, personalized cancer vaccines have gained increasing attention as emerging immunotherapies with the capability to overcome interindividual differences and show great benefits for individual patients in the clinic due to the highly tailored… read more here.
Keywords: delivery; therapeutic performance; personalized cancer; vaccine ... See more keywords
Selectively Fluorinated PAMAM-Arginine Conjugates as Gene Delivery Vectors.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.3c00139
Abstract: Polyamidoamine (PAMAM) dendrimers are among the most studied cationic polymers as non-viral gene delivery vectors. However, an "ideal" PAMAM-based gene delivery vector is still missing due to the high manufacturing costs and non-negligible cytotoxicity associated… read more here.
Keywords: delivery vectors; arginine; pamam; gene delivery ... See more keywords
A Kinetic Model of Oligonucleotide-Brush Interactions for the Rational Design of Gene Delivery Vectors.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b00155
Abstract: Polymer brushes are attractive candidates for the design of gene delivery vectors as they allow the systematic study of the impact of structural (type, size, and shape of nanomaterials core) and physicochemical parameters (cationic monomer… read more here.
Keywords: delivery; gene delivery; model; design gene ... See more keywords
Sulfonium Lipids: Synthesis and Evaluation as DNA Delivery Vectors.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220519122622
Abstract: BACKGROUND Cationic lipids can be used as nonviral vectors in gene delivery therapy. Most cationic lipids contain quaternary ammonium that can bond to negative phosphates of the plasmid. In this study, sulfonium-a trialkylated sulfur cation… read more here.
Keywords: sulfonium lipids; dna; delivery vectors; synthesis ... See more keywords
Advances in delivery vectors for gene therapy in liver cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Therapeutic delivery"
DOI: 10.4155/tde-2019-0076
Abstract: Hepatocellular carcinoma (HCC) is the third most common cause of cancer death globally, mainly due to lack of effective treatments - a problem that gene therapy is poised to solve. Successful gene therapy requires safe and efficient… read more here.
Keywords: gene; hcc gene; gene therapy; delivery vectors ... See more keywords