Amino‐Bisphosphonates and Cardiovascular Risk: A New Hypothesis Involving the Effects on Gamma‐Delta T Cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3660
Abstract: We read with much interest the article by Sing and colleagues recently published in the Journal. The authors used propensityscore matching to evaluate the risk of cardiovascular (CV) mortality and CV events in amino-bisphosphonate (N-BP)… read more here.
Keywords: risk; amino bisphosphonates; gamma delta; reduction risk ... See more keywords
Reciprocal alterations in circulating and hepatic gamma–delta T cells in patients with primary biliary cholangitis
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology International"
DOI: 10.1007/s12072-021-10267-7
Abstract: Background and aims Gamma–delta (γδ) T cells are involved in the development of diverse liver and autoimmune diseases, whereas the role of γδ T cells in primary biliary cholangitis (PBC) remains unclear. Methods We analyzed… read more here.
Keywords: gamma delta; tcr low; tcr; primary biliary ... See more keywords
Characterization of circulating gamma-delta T cells in relapsing vs remission multiple sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2018.02.009
Abstract: We characterized circulating gamma-delta T cells in relapsing-remitting multiple sclerosis (RRMS) patients, during remission and relapse phases. In relapse, we observed a decrease of circulating CCR5+ γδ TEMRA cell subset, together with a decrease in… read more here.
Keywords: gamma delta; cells relapsing; multiple sclerosis; circulating gamma ... See more keywords
Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101060
Abstract: Objectives The main endocrine cell types in pancreatic islets are alpha, beta, and delta cells. Although these cell types have distinct roles in the regulation of glucose homeostasis, inadequate purification methods preclude the study of… read more here.
Keywords: beta cells; metabolism; beta; iron ... See more keywords
Structural basis for delta cell paracrine regulation in pancreatic islets
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11517-x
Abstract: Little is known about the role of islet delta cells in regulating blood glucose homeostasis in vivo. Delta cells are important paracrine regulators of beta cell and alpha cell secretory activity, however the structural basis… read more here.
Keywords: delta; beta; delta cell; cell ... See more keywords
Synthetic retinoid AM80 inhibits IL‐17 production of gamma delta T cells and ameliorates biliary atresia in mice
Sign Up to like & getrecommendations! Published in 2020 at "Liver International"
DOI: 10.1111/liv.14639
Abstract: Recent evidence suggests that Interleukin (IL)‐17‐producing gamma delta ( γδ ) T cells are the dominant pathogenic cellular component in designated autoimmune or inflammatory diseases, including biliary atresia (BA). We have previously demonstrated that retinoids… read more here.
Keywords: biliary atresia; gamma delta; delta cells;
Abstract 2187: Epigenetic monitoring of gamma delta T-cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2187
Abstract: Human gamma delta T cells (γδ-T cells) are non-conventional T lymphocytes expressing a TCR heterodimer comprised of gamma (γ) and delta (δ) chains. They constitute an essential part of the innate immune system playing a… read more here.
Keywords: delta cells; cell; gamma delta; epigenetic monitoring ... See more keywords
What Can Gamma Delta T Cells Contribute to an HIV Cure?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00233
Abstract: Elimination of the latent HIV reservoir remains a major barrier to achieving an HIV cure. In this review, we discuss the cytolytic nature of human gamma delta T cells and highlight the emerging evidence that… read more here.
Keywords: hiv cure; gamma delta; delta cells;
Staphylococcus epidermidis Boosts Innate Immune Response by Activation of Gamma Delta T Cells and Induction of Perforin-2 in Human Skin
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.550946
Abstract: Perforin-2 (P-2) is an antimicrobial protein with unique properties to kill intracellular bacteria. Gamma delta (GD) T cells, as the major T cell population in epithelial tissues, play a central role in protective and pathogenic… read more here.
Keywords: skin; gamma delta; human skin; immune response ... See more keywords
How to Train Your Dragon: Harnessing Gamma Delta T Cells Antiviral Functions and Trained Immunity in a Pandemic Era
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.666983
Abstract: The emergence of viruses with pandemic potential such as the SARS-CoV-2 coronavirus causing COVID-19 poses a global health challenge. There is remarkable progress in vaccine technology in response to this threat, but their design often… read more here.
Keywords: trained immunity; antiviral functions; gamma delta; delta cells ... See more keywords
Innervation modulates the functional connectivity between pancreatic endocrine cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.64526
Abstract: The importance of pancreatic endocrine cell activity modulation by autonomic innervation has been debated. To investigate this question, we established an in vivo imaging model that also allows chronic and acute neuromodulation with genetic and… read more here.
Keywords: innervation; activity; connectivity pancreatic; delta cells ... See more keywords