Expression of delta-like protein 3 is reproducibly present in a subset of small cell lung carcinomas and pulmonary carcinoid tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.07.016
Abstract: OBJECTIVES Delta-like protein 3 (DLL3), an inhibitory Notch ligand, is the target for rovalpituzumab tesirine in development for the treatment of small cell lung cancer (SCLC). We studied the expression of DLL3, its reproducibility and… read more here.
Keywords: dll3; expression; lung; carcinoid tumors ... See more keywords
Delta-like ligand 3–targeted radioimmunotherapy for neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203820119
Abstract: Significance Neuroendocrine prostate cancer (NEPC) is a highly aggressive variant of prostate cancer with few meaningful treatment options. As a result, patients have a poor prognosis once diagnosis is confirmed. NEPC expresses a unique protein… read more here.
Keywords: prostate cancer; prostate; neuroendocrine prostate; like ligand ... See more keywords
Delta-like ligand 3 (DLL3): an attractive actionable target in tumors with neuroendocrine origin
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2022.2071703
Abstract: ABSTRACT Introduction Neuroendocrine carcinomas are very aggressive tumors with few treatment options. DLL3 seems to be an optimal target for therapeutic intervention, as it is expressed mainly on the membrane of tumor cells with neuroendocrine… read more here.
Keywords: neuroendocrine origin; ligand dll3; target; like ligand ... See more keywords
Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview
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DOI: 10.1111/cas.15017
Abstract: Delta‐like canonical Notch ligand 3 (DLL3) is a member of the Delta/Serrate/Lag2 (DSL) Notch receptor ligand family and plays a crucial role in Notch signaling, which influences various cellular processes including differentiation, proliferation, survival, and… read more here.
Keywords: like canonical; notch ligand; delta like; notch ... See more keywords
Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung
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DOI: 10.1172/jci.insight.134170
Abstract: The molecular mechanisms by which endothelial cells (ECs) regulate pulmonary vascularization and contribute to alveolar epithelial cell development during lung morphogenesis remain unknown. We tested the hypothesis that delta-like 4 (DLL4), an EC Notch ligand,… read more here.
Keywords: delta like; lung; mice; alveolarization ... See more keywords
Silencing Delta-like 1 Expression Induces Migratory Features in Pancreatic Cancer Cells Through Stimulation of Src and p38 Signalling Pathway
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DOI: 10.21873/anticanres.14075
Abstract: Background/Aim: The prognosis of pancreatic cancer has not improved due to its migratory feature and refractory potential to chemo-resistance with absence of effective diagnosis. Despite continuous efforts, its underlying mechanisms of malignant nature remain ambiguous.… read more here.
Keywords: dll1; delta like; pancreatic cancer; expression ... See more keywords
Delta Like-1 Gene Mutation: A Novel Cause of Congenital Vertebral Malformation
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DOI: 10.3389/fgene.2019.00534
Abstract: Skeletal development throughout the embryonic and postnatal phases is a dynamic process, based on bone remodeling and the balance between the activities of osteoclasts and osteoblasts modulating skeletal homeostasis. The Notch signaling pathway is a… read more here.
Keywords: congenital vertebral; delta like; notch; gene ... See more keywords
Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin
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DOI: 10.3389/fmicb.2021.652962
Abstract: Hepatitis delta virus (HDV) is a human pathogen, and the only known species in the genus Deltavirus. HDV is a satellite virus and depends on the hepatitis B virus (HBV) for packaging, release, and transmission.… read more here.
Keywords: hepatitis delta; delta; delta like; like agents ... See more keywords
Pituitary Tumor-Transforming Gene 1/Delta like Non-Canonical Notch Ligand 1 Signaling in Chronic Liver Diseases
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DOI: 10.3390/ijms23136897
Abstract: The management of chronic liver diseases (CLDs) remains a challenge, and identifying effective treatments is a major unmet medical need. In the current review we focus on the pituitary tumor transforming gene (PTTG1)/delta like non-canonical… read more here.
Keywords: pituitary tumor; tumor transforming; liver diseases; transforming gene ... See more keywords