Delta‐Like Homolog 2 Facilitates Malignancy of Hepatocellular Carcinoma via Activating EGFR/PKM2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23836
Abstract: Delta‐like homolog 2 (DLK2) plays a crucial role in adipogenesis, chondrogenic differentiation, and the progression of certain cancers. However, the key roles of DLK2 underlying the progression of hepatocellular carcinoma (HCC) remain ambiguous. In the… read more here.
Keywords: delta like; hepatocellular carcinoma; progression; like homolog ... See more keywords
Delta‐like ligand 4 inhibitor drug treatment induces pulmonary hypertension in cancer clinical trials
Sign Up to like & getrecommendations! Published in 2024 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12450
Abstract: Abstract Delta‐like ligand 4 (DLL‐4) inhibitor drugs are an emerging cancer treatment. In clinical trials for solid organ malignancies, intravenous administration of monoclonal antibodies that inhibit DLL‐4 is associated with development of pulmonary hypertension, in… read more here.
Keywords: delta like; clinical trials; like ligand; pulmonary hypertension ... See more keywords
Expression of delta-like protein 3 is reproducibly present in a subset of small cell lung carcinomas and pulmonary carcinoid tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.07.016
Abstract: OBJECTIVES Delta-like protein 3 (DLL3), an inhibitory Notch ligand, is the target for rovalpituzumab tesirine in development for the treatment of small cell lung cancer (SCLC). We studied the expression of DLL3, its reproducibility and… read more here.
Keywords: dll3; expression; lung; carcinoid tumors ... See more keywords
Association of elevated Delta-like canonical Notch ligand 1 levels with clinical outcomes in patients hospitalized for SARS-CoV2 infection
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-03673-6
Abstract: Soluble Delta-like ligand 1 (sDLL1) has demonstrated promising results as an early biomarker of bacterial sepsis, but its role in viral infections remains unclear. This study investigated the association between sDLL1 levels and clinical outcomes… read more here.
Keywords: clinical outcomes; sdll1; sdll1 group; levels clinical ... See more keywords
Delta-like ligand 3–targeted radioimmunotherapy for neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203820119
Abstract: Significance Neuroendocrine prostate cancer (NEPC) is a highly aggressive variant of prostate cancer with few meaningful treatment options. As a result, patients have a poor prognosis once diagnosis is confirmed. NEPC expresses a unique protein… read more here.
Keywords: prostate cancer; prostate; neuroendocrine prostate; like ligand ... See more keywords
Delta-like ligand 3 (DLL3): an attractive actionable target in tumors with neuroendocrine origin
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2022.2071703
Abstract: ABSTRACT Introduction Neuroendocrine carcinomas are very aggressive tumors with few treatment options. DLL3 seems to be an optimal target for therapeutic intervention, as it is expressed mainly on the membrane of tumor cells with neuroendocrine… read more here.
Keywords: neuroendocrine origin; ligand dll3; target; like ligand ... See more keywords
Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.15017
Abstract: Delta‐like canonical Notch ligand 3 (DLL3) is a member of the Delta/Serrate/Lag2 (DSL) Notch receptor ligand family and plays a crucial role in Notch signaling, which influences various cellular processes including differentiation, proliferation, survival, and… read more here.
Keywords: like canonical; notch ligand; delta like; notch ... See more keywords
Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.134170
Abstract: The molecular mechanisms by which endothelial cells (ECs) regulate pulmonary vascularization and contribute to alveolar epithelial cell development during lung morphogenesis remain unknown. We tested the hypothesis that delta-like 4 (DLL4), an EC Notch ligand,… read more here.
Keywords: delta like; lung; mice; alveolarization ... See more keywords
Silencing Delta-like 1 Expression Induces Migratory Features in Pancreatic Cancer Cells Through Stimulation of Src and p38 Signalling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "AntiCancer Research"
DOI: 10.21873/anticanres.14075
Abstract: Background/Aim: The prognosis of pancreatic cancer has not improved due to its migratory feature and refractory potential to chemo-resistance with absence of effective diagnosis. Despite continuous efforts, its underlying mechanisms of malignant nature remain ambiguous.… read more here.
Keywords: dll1; delta like; pancreatic cancer; expression ... See more keywords
Delta Like-1 Gene Mutation: A Novel Cause of Congenital Vertebral Malformation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00534
Abstract: Skeletal development throughout the embryonic and postnatal phases is a dynamic process, based on bone remodeling and the balance between the activities of osteoclasts and osteoblasts modulating skeletal homeostasis. The Notch signaling pathway is a… read more here.
Keywords: congenital vertebral; delta like; notch; gene ... See more keywords
Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.652962
Abstract: Hepatitis delta virus (HDV) is a human pathogen, and the only known species in the genus Deltavirus. HDV is a satellite virus and depends on the hepatitis B virus (HBV) for packaging, release, and transmission.… read more here.
Keywords: hepatitis delta; delta; delta like; like agents ... See more keywords