The delta opioid peptide D‐Alanine 2, Leucine 5 Enkephaline (DADLE)‐induces neuroprotection through cross‐talk between the UPR and pro‐survival MAPK‐NGF‐Bcl2 signaling pathways via modulation of several micro‐RNAs in SH‐SY5Y cells subjected to ER stress
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DOI: 10.1002/cbin.10923
Abstract: Parkinson's disease (PD) is the second most progressive neurodegenerative disease characterized by the loss of dopaminergic neurons and accumulation of misfolded proteins in endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR).… read more here.
Keywords: sy5y cells; peptide alanine; cells subjected; delta opioid ... See more keywords
Mu and delta opioid receptor knockout mice show increased colonic sensitivity
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DOI: 10.1002/ejp.965
Abstract: Opiates act through opioid receptors to diminish pain. Here, we investigated whether mu (MOR) and delta (DOR) receptor endogenous activity assessed in the whole mouse body or in particular at peripheral receptors on primary nociceptive… read more here.
Keywords: opioid receptor; knockout mice; delta opioid; receptor ... See more keywords
Delta Opioid Receptors: Learning and Motivation.
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DOI: 10.1007/164_2016_89
Abstract: Delta opioid receptor (DOR) displays a unique, highly conserved, structure and an original pattern of distribution in the central nervous system, pointing to a distinct and specific functional role among opioid peptide receptors. Over the… read more here.
Keywords: receptors learning; pharmacology; opioid receptors; delta opioid ... See more keywords
Delta Opioid Receptors and Modulation of Mood and Emotion.
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DOI: 10.1007/164_2017_42
Abstract: Depression is a pervasive and debilitating mental disorder that is inadequately treated by current pharmacotherapies in a majority of patients. Although opioids have long been known to regulate mood states, the use of opioids to… read more here.
Keywords: dor agonists; like effects; mood; delta opioid ... See more keywords
Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons.
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DOI: 10.1007/164_2017_58
Abstract: The functional diversity of primary afferent neurons of the dorsal root ganglia (DRG) generates a variety of qualitatively and quantitatively distinct somatosensory experiences, from shooting pain to pleasant touch. In recent years, the identification of… read more here.
Keywords: opioid receptor; somatosensory; primary afferent; dor ... See more keywords
Delta‐opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice
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DOI: 10.1016/j.ejphar.2019.04.009
Abstract: ABSTRACT Oxycodone, a widely prescribed and very potent oral opioid analgesic agent, is highly addictive and has many side effects, including troublesome constipation. Our studies in mice indicated that pretreatment of naltrindole did not significantly… read more here.
Keywords: opioid receptor; mice; delta opioid; constipation ... See more keywords
Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon
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DOI: 10.1016/j.jcmgh.2019.11.006
Abstract: Background & Aims Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for… read more here.
Keywords: mor; dor; functionally interact; enteric nervous ... See more keywords
Delta opioid receptor agonists are effective for multiple types of headache disorders
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DOI: 10.1016/j.neuropharm.2018.12.017
Abstract: ABSTRACT Headaches are highly disabling and are among the most common neurological disorders worldwide. Despite the high prevalence of headache, therapeutic options are limited. We recently identified the delta opioid receptor (DOR) as an emerging… read more here.
Keywords: migraine; opioid receptor; delta opioid; headache ... See more keywords
Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity
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DOI: 10.1016/j.neuropharm.2020.108307
Abstract: Opioid signaling controls the activity of the brain's reward system. It is involved in signaling the hedonic effects of rewards and has essential roles in reinforcement and motivational processes. Here, we focused on opioid signaling… read more here.
Keywords: effect; dopamine receptor; delta opioid; receptor ... See more keywords
A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors.
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DOI: 10.1021/acschemneuro.7b00485
Abstract: Physiological responses to the opioid neuropeptide enkephalin often involve both mu and delta opioid receptors. To facilitate quantitative studies into opioid signaling, we previously developed a caged [Leu5]-enkephalin that responds to ultraviolet irradiation, but its… read more here.
Keywords: enkephalin optimized; optimized simultaneously; residual activity; caged enkephalin ... See more keywords
Substance P and dopamine interact to modulate the distribution of delta‐opioid receptors on cholinergic interneurons in the striatum
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DOI: 10.1111/ejn.13750
Abstract: It has been recently demonstrated that predictive learning induces a persistent accumulation of delta‐opioid receptors (DOPrs) at the somatic membrane of cholinergic interneurons (CINs) in the nucleus accumbens shell (Nac‐S). This accumulation is required for… read more here.
Keywords: dopr translocation; translocation; opioid receptors; cholinergic interneurons ... See more keywords