Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer’s disease
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DOI: 10.1016/j.pneurobio.2021.102113
Abstract: Asparagine endopeptidase (AEP), a newly identified delta-secretase, simultaneously cleaves both APP and Tau, promoting Alzheimer's disease (AD) pathologies. However, its pathological role in AD remains incompletely understood. Here we show that delta-secretase cleaves BACE1, a… read more here.
Keywords: delta beta; delta secretase; alzheimer disease; beta secretases ... See more keywords