Delta‐9‐tetrahydrocannabinol decreases masticatory muscle sensitization in female rats through peripheral cannabinoid receptor activation
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pain"
DOI: 10.1002/ejp.1085
Abstract: This study investigated whether intramuscular injection of delta‐9‐tetrahydrocannabinol (THC), by acting on peripheral cannabinoid (CB) receptors, could decrease nerve growth factor (NGF)‐induced sensitization in female rat masseter muscle; a model which mimics the symptoms of… read more here.
Keywords: peripheral cannabinoid; muscle; sensitization female; delta tetrahydrocannabinol ... See more keywords
Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05273-5
Abstract: AbstractRationaleThe catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human brain.ObjectiveThis study was designed to evaluate the effect of (1) a functional polymorphism and… read more here.
Keywords: methyl transferase; delta tetrahydrocannabinol; study; acute response ... See more keywords
In an exploratory randomized, double-blind, placebo-controlled, cross-over study, psychoactive doses of intravenous delta-9-tetrahydrocannabinol fail to produce antinociceptive effects in healthy human volunteers
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05595-9
Abstract: Animal studies and anecdotal human reports suggest that cannabinoids have antinociceptive effects. Controlled human studies have produced mixed results. We sought to reduce existing variability by investigating the effects of intravenous delta-9-tetrahydrocannabinol (THC) in several… read more here.
Keywords: healthy human; antinociceptive effects; study; delta tetrahydrocannabinol ... See more keywords
The effects of delta-9-tetrahydrocannabinol (THC) on inflammation: A review.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104111
Abstract: THC is the main psychoactive compound found in marijuana. A number of studies over the past few decades, both in vitro and in vivo, have demonstrated that THC down-regulates the inflammatory process through various mechanisms.… read more here.
Keywords: delta tetrahydrocannabinol; inflammation; tetrahydrocannabinol thc; review ... See more keywords
The effect of delta-9-tetrahydrocannabinol and cannabidiol on p50 of the oxygen haemoglobin dissociation curve.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104539
Abstract: Cannabis is one of the most chemically complex plants containing a large number of compounds, among which are cannabinoids; the main biologically active constituents of the plant. Delta-9-tetrahydrocannabinol (THC) is known as the main psychoactive… read more here.
Keywords: oxygen; delta tetrahydrocannabinol; p50 oxygen; thc cbd ... See more keywords
A crowdsourcing survey study on the subjective effects of delta-8-tetrahydrocannabinol relative to delta-9-tetrahydrocannabinol and cannabidiol.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental and clinical psychopharmacology"
DOI: 10.1037/pha0000565
Abstract: Delta-8-tetrahydrocannabinol (Δ8-THC) has emerged as a new retail cannabinoid product in the U.S. This study queried Δ8-THC users about product use characteristics and self-reported drug effects. Participants were recruited via a large online crowdsourcing platform… read more here.
Keywords: drug; delta tetrahydrocannabinol; thc; study ... See more keywords
Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0374-8
Abstract: The neurobiological mechanisms underlying the association between cannabis use and acute or long-lasting psychosis are not completely understood. While some evidence suggests altered striatal dopamine may underlie the association, direct evidence that cannabis use affects… read more here.
Keywords: cannabis; glutamate levels; striatal glutamate; delta tetrahydrocannabinol ... See more keywords
Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study.
Sign Up to like & getrecommendations! Published in 2022 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2022.0174
Abstract: Background: The effects of cannabis are thought to be mediated by interactions between its constituents and the endocannabinoid system. Delta-9-tetrahydrocannabinol (THC) binds to central cannabinoid receptors, while cannabidiol (CBD) may influence endocannabinoid function without directly… read more here.
Keywords: healthy volunteers; delta tetrahydrocannabinol; randomized double; double blind ... See more keywords
Assessing Characteristics and Compliance of Online Delta-8 Tetrahydrocannabinol Product Sellers.
Sign Up to like & getrecommendations! Published in 2023 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2022.0341
Abstract: Introduction: The debate over the legal status of many cannabis- and hemp-derived products, including delta-8 tetrahydrocannabinol (THC), is in question. Although low concentrations of delta-8 THC are legal at the Federal level, many states have… read more here.
Keywords: delta; delta tetrahydrocannabinol; online delta; delta thc ... See more keywords
Transfer of Inhaled Cannabis Into Human Breast Milk.
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DOI: 10.1097/aog.0000000000002575
Abstract: OBJECTIVE To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis containing 23.18% delta-9-tetrahydrocannabinol. METHODS In this pilot pharmacokinetic study, breast milk samples were collected… read more here.
Keywords: milk; breast milk; delta tetrahydrocannabinol; transfer ... See more keywords
Variable Delta-9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics After Cannabis Smoking in Regular Users.
Sign Up to like & getrecommendations! Published in 2023 at "Therapeutic drug monitoring"
DOI: 10.1097/ftd.0000000000001104
Abstract: BACKGROUND Despite its federally restricted status, cannabis is widely used medicinally and recreationally. The pharmacokinetics (PK) and central nervous system (CNS) effects of tetrahydrocannabinol (THC), the major psychoactive cannabinoid, are not well understood. The objective… read more here.
Keywords: thc concentrations; delta tetrahydrocannabinol; population model; model ... See more keywords