Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain
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DOI: 10.1128/aac.02098-16
Abstract: ABSTRACT Chagas disease is a life-threatening infection caused by a variety of genetically diverse strains of the protozoan parasite Trypanosoma cruzi. The current treatment (benznidazole and nifurtimox) is unsatisfactory, and potential alternatives include inhibitors of… read more here.
Keywords: sterol demethylase; cruzi; demethylase cyp51; cyp51 ... See more keywords
Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review
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DOI: 10.12688/f1000research.125645.2
Abstract: Mycoses or fungal infections are general health problem that often occurs in healthy and immunocompromised people in the community. The development of resistant strains in Fungi and the incidence of azole antibiotic resistance in the… read more here.
Keywords: demethylase; phytochemical profiling; review; lanosterol ... See more keywords