Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113662
Abstract: Histone lysine demethylase 4D (KDM4D) plays an important role in the regulation of tumorigenesis, progression and drug resistance and has been considered a potential target for cancer treatment. However, there is still a lack of… read more here.
Keywords: potent selective; histone lysine; demethylase kdm4d; kdm4d ... See more keywords
Histone demethylase KDM4D inhibition suppresses renal cancer progression and angiogenesis through JAG1 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death discovery"
DOI: 10.1038/s41420-021-00682-y
Abstract: Kidney cancer, especially clear cell renal cell carcinoma (ccRCC), is one of the representative genitourinary tumors. Investigation of underlying mechanisms of ccRCC development is crucial for patient management. Histone demethylase KDM4D has been reported to… read more here.
Keywords: ccrcc; histone demethylase; cancer; demethylase kdm4d ... See more keywords
H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw848
Abstract: DNA replication is tightly regulated to occur once and only once per cell cycle. How chromatin, the physiological substrate of DNA replication machinery, regulates DNA replication remains largely unknown. Here we show that histone H3… read more here.
Keywords: regulates dna; dna replication; formation pre; demethylase kdm4d ... See more keywords