Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3
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DOI: 10.1038/s41388-020-01449-y
Abstract: Aberrations in epigenetic modulation dysregulate transcription, playing a critical role in the developmental process of tumors, including lung cancer. Aberrant levels of the histone 3 lysine-27 demethylase KDM6A have been found in cancer and are… read more here.
Keywords: histone lysine; demethylase kdm6a; role; cancer ... See more keywords
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer
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DOI: 10.1136/gutjnl-2021-325405
Abstract: Objective Large-scale genome sequencing efforts of human tumours identified epigenetic modifiers as one of the most frequently mutated gene class in human cancer. However, how these mutations drive tumour development and tumour progression are largely… read more here.
Keywords: kdm6a deficient; demethylase kdm6a; mtorc1; cancer ... See more keywords