Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/β‐catenin signaling
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13236
Abstract: Tumor metastasis remains a major challenge for patients with breast cancer. Aberrant epigenetic factor lysine‐specific demethylase 6B (KDM6B) has been associated with tumor progression. Here, we show that KDM6B is significantly down‐regulated in human breast… read more here.
Keywords: catenin; breast cancer; metastasis; cancer ... See more keywords
The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.08.030
Abstract: ABSTRACT Epigenetic remodeling contributes to synaptic plasticity via modification of gene expression, which underlies cocaine‐induced long‐term memory. A prevailing hypothesis in drug addiction is that drugs of abuse rejuvenate developmental machinery to render reward circuitry… read more here.
Keywords: drug; cocaine induced; cocaine; memory ... See more keywords
The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae
Sign Up to like & getrecommendations! Published in 2020 at "Nature Microbiology"
DOI: 10.1038/s41564-020-00805-8
Abstract: Streptococcus pneumoniae is a natural colonizer of the human respiratory tract and an opportunistic pathogen. Although epithelial cells are among the first to encounter pneumococci, the cellular processes and contribution of epithelial cells to the… read more here.
Keywords: histone demethylase; response; host response; streptococcus pneumoniae ... See more keywords