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   Articles with "demethylase lsd1" as a keyword



Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis

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recommendations! Published in 2022 at "Nature Communications"

DOI: 10.1038/s41467-022-28107-z

Abstract: Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a… read more here.

Keywords: chromatin; neural cells; demethylase lsd1; nematostella vectensis ... See more keywords

Lysine-specific demethylase 1A (LSD1) restricts ex vivo propagation of human HSCs and is a target of UM171.

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood.2020005827

Abstract: Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator Lysine-specific histone demethylase 1A (LSD1) induces a rapid… read more here.

Keywords: hscs; demethylase lsd1; lysine specific;
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Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases

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recommendations! Published in 2021 at "Journal of Biomedical Science"

DOI: 10.1186/s12929-021-00737-3

Abstract: Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a… read more here.

Keywords: lysine specific; cancer; demethylase lsd1; specific demethylase ... See more keywords

An Overview on Screening Methods for Lysine Specific Demethylase 1 (LSD1) Inhibitors.

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recommendations! Published in 2017 at "Current medicinal chemistry"

DOI: 10.2174/0929867324666170509114321

Abstract: BACKGROUND In the past few years, great of attention has been paid to the identification and characterization of selective and potent inhibitors of the first identified histone demethylase LSD1, which may erase mono- and di-methylated… read more here.

Keywords: lsd1 inhibitor; lsd1 inhibitors; chemistry; demethylase lsd1 ... See more keywords