Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26
Sign Up to like & getrecommendations! Published in 2018 at "Febs Letters"
DOI: 10.1002/1873-3468.13231
Abstract: N‐Methylation of lysyl residues is widely observed on histone proteins. Using isolated enzymes, we report mechanistic and structural studies on histone lysine demethylase (KDM)‐catalysed demethylation of Nε‐methylated lysine 26 on histone 1 isotype 4 (H1.4).… read more here.
Keywords: kdm catalysed; demethylation; structural studies; catalysed demethylation ... See more keywords
The catalytic domains of all human KDM5 JmjC demethylases catalyse N‐methyl arginine demethylation
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14586
Abstract: The demethylation of Nε‐methyllysine residues on histones by Jumonji‐C lysine demethylases (JmjC‐KDMs) has been established. A subset of JmjC‐KDMs has also been reported to have Nω‐methylarginine residue demethylase (RDM) activity. Here, we describe biochemical screening… read more here.
Keywords: jmjc; demethylation; catalytic domains; human kdm5 ... See more keywords
A stable association with PME‐1 may be dispensable for PP2A demethylation – implications for the detection of PP2A methylation and immunoprecipitation
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12485
Abstract: Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme. Accumulating evidence links PP2Ac methylation to diseases, including cancer and neurodegenerative disorders. Protein… read more here.
Keywords: stable association; methylation; association pme; demethylation ... See more keywords
Exploring the Selective Demethylation of Aryl Methyl Ethers with a Pseudomonas Rieske Monooxygenase
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800594
Abstract: Biocatalytic dealkylation of aryl methyl ethers is an attractive reaction for valorization of lignin components, as well as for deprotection of hydroxy functionalities in synthetic chemistry. We explored the demethylation of various aryl methyl ethers… read more here.
Keywords: rieske monooxygenase; aryl methyl; methyl ethers; demethylation ... See more keywords
Low‐dose radiation‐induced demethylation of 3β‐HSD participated in the regulation of testosterone content
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4237
Abstract: The effects of low‐dose radiation (LDR, ≤0.1 Gy) on living organisms have been the hot areas of radiation biology but do not reach a definitive conclusion yet. So far, few studies have adequately accounted for… read more here.
Keywords: demethylation; testosterone; hsd; low dose ... See more keywords
JMJD3 downregulates IL4i1 aggravating lipopolysaccharide‐induced acute lung injury via H3K27 and H3K4 demethylation
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23725
Abstract: The pro‐inflammation M1 to anti‐inflammation M2 macrophage ratio contribute to the severity of lipopolysaccharide (LPS)‐induced acute lung injury (ALI). JMJD3 aggravates the inflammatory reaction through affecting epigenetic modification and macrophage's phenotype to deteriorate ALI. To… read more here.
Keywords: macrophage ratio; demethylation; jmjd3; induced acute ... See more keywords
Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.011
Abstract: FTO, the first RNA demethylase discovered, mediates the demethylation of internal N6-methyladenosine (m6A) and N6, 2-O-dimethyladenosine (m6Am) at the +1 position from the 5' cap in mRNA. Here we demonstrate that the cellular distribution of FTO… read more here.
Keywords: m6am; demethylation; m6a; cell ... See more keywords
The potential of mercury methylation and demethylation by 15 species of marine microalgae.
Sign Up to like & getrecommendations! Published in 2022 at "Water research"
DOI: 10.1016/j.watres.2022.118266
Abstract: Mercury (Hg) and its compounds are a kind of worldwide concerned persistent toxic pollutants. As the major primary producer in the ocean, microalgae are expected to play an important role in the cycling and accumulation… read more here.
Keywords: demethylation; methylation demethylation; mercury; microalgae ... See more keywords
Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00683
Abstract: A precise balance of DNA methylation and demethylation is required for epigenetic control of cell identity, development, and growth. DNA methylation marks are introduced by de novo DNA methyltransferases DNMT3a/b and are maintained throughout cell… read more here.
Keywords: dna; demethylation; oxidized forms; dna demethylation ... See more keywords
Plasmon-Enhanced Autocatalytic N-Demethylation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.8b07078
Abstract: Increasing experimental results indicate that optically excited plasmonic metal nanoparticles can drive photochemical reactions at photon flux comparable to that of solar radiation. However, experimental evidence that provides insight into the mechanism of the reactions… read more here.
Keywords: plasmon enhanced; demethylation; enhanced autocatalytic; spectroscopy ... See more keywords
Reprogrammable CRISPR/dCas9-based recruitment of DNMT1 for site-specific DNA demethylation and gene regulation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Discovery"
DOI: 10.1038/s41421-019-0090-1
Abstract: Dear Editor, DNA methylation and demethylation play a critical role in regulating gene expression as well as developmental and pathological processes. For example, hypermethylation in the promoter region typically represses a gene’s transcription, and aberrant… read more here.
Keywords: methylation; dcas9; crispr; dna ... See more keywords