Universal Strategy to Develop Fluorogenic Probes for Lysine Deacylase/Demethylase Activity and Application in Discriminating Demethylation States.
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DOI: 10.1021/acssensors.2c01345
Abstract: Dynamically controlling the post-translational modification of the ε-amino groups of lysine residues is critical for regulating many cellular events. Increasing studies have revealed that many important diseases, including cancer and neurological disorders, are associated with… read more here.
Keywords: demethylase; demethylation states; universal strategy; activity ... See more keywords