Durvalumab and multiple sclerosis: a causal link or simple unmasking?
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02959-0
Abstract: Dear Sirs, Immune checkpoint inhibitors (ICIs) became the new milestone of the immune-oncology therapy. This family includes three drug classes: anti-cytotoxic T lymphocyte–associated protein4 (CTLA4), anti-programmed cell death 1 (PD-1), and anti-programmed death-ligand 1 (PD-L1).… read more here.
Keywords: durvalumab; anti; multiple sclerosis; therapy ... See more keywords
Successful treatment of HIV-associated tumefactive demyelinating lesions with corticosteroids and cyclophosphamide: a case report
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-10296-6
Abstract: A 43-year-old, previously healthy man presented to the emergency department due to subacute onset, in the previous month, of behavioral changes and speech impairment. Head CT scan revealed two large subcortical hypodense lesions in both… read more here.
Keywords: brain mri; demyelinating lesions; hiv; tumefactive demyelinating ... See more keywords
The coexistence of recurrent cerebral tumefactive demyelinating lesions with longitudinally extensive transverse myelitis and demyelinating neuropathy.
Sign Up to like & getrecommendations! Published in 2019 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2018.11.002
Abstract: Combined central and peripheral demyelination (CCPD) is a rare chronic inflammatory disorder of the nervous system. In this article, we report on a CCPD patient with a very unusual pattern of central demyelination, comprising recurrent… read more here.
Keywords: recurrent cerebral; longitudinally extensive; extensive transverse; cerebral tumefactive ... See more keywords
Supratentorial Demyelinating Lesions Following Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Pediatric Case Report
Sign Up to like & getrecommendations! Published in 2022 at "Neuropediatrics"
DOI: 10.1055/s-0042-1757710
Abstract: Abstract Introduction Most coronavirus disease 2019 (COVID-19) pediatric patients are asymptomatic; however, several neurological manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have been reported. Demyelinating events such as acute disseminated encephalomyelitis have… read more here.
Keywords: severe acute; infection; coronavirus; case ... See more keywords
Multifocal and Multiphasic Demyelinating Lesions After Radiation for Ependymoma in a Pediatric Population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Child Neurology"
DOI: 10.1177/08830738221079476
Abstract: Radiation treatment is widely used to address unresectable intracranial tumors. Owing to the nature of therapy, healthy tissue and diseased regions will be affected. New insights have shown that not only does this impact brain… read more here.
Keywords: lesions radiation; brain; multiphasic demyelinating; multifocal multiphasic ... See more keywords
Demyelinating lesions and progressive MS
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000007933
Abstract: In multiple sclerosis (MS), the majority of patients experience neurologic relapses followed by recovery and later—on average 10 to 15 years after onset in adult patients1,2 and 20 years after onset in pediatric patients3—develop progressive… read more here.
Keywords: lesions progressive; injury; demyelinating lesions;
Pearls & Oy-sters: Tumefactive Demyelinating Lesions With MOG Antibodies Preceding Late Infantile Metachromatic Leukodystrophy
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201230
Abstract: The development of acute neurologic dysfunction associated with tumefactive demyelinating lesions and mild diffuse involvement of the corpus callosum has been described in children as a sentinel event that may allow diagnosis of juvenile metachromatic… read more here.
Keywords: pearls sters; late infantile; metachromatic leukodystrophy; tumefactive demyelinating ... See more keywords
MRI Findings in Tumefactive Demyelinating Lesions: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a5775
Abstract: BACKGROUND: Accurate diagnosis of tumefactive demyelinating lesions is clinically important to avoid unnecessary invasive biopsy or inappropriate treatment. PURPOSE: We aimed to evaluate conventional and advanced MR imaging findings of tumefactive demyelinating lesions and determine… read more here.
Keywords: imaging findings; findings tumefactive; lesions primary; tumefactive demyelinating ... See more keywords