Demyelination induced by oxidative stress is regulated by sphingosine 1‐phosphate receptors
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DOI: 10.1002/glia.23148
Abstract: Oxidative stress is a pathological condition defined as an imbalance between production and removal of reactive oxygen species. This process causes structural cell damage, disrupts DNA repair and induces mitochondrial dysfunction. Many in vitro studies… read more here.
Keywords: demyelination; gox cat; induced oxidative; oxidative stress ... See more keywords
Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone‐induced demyelination
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DOI: 10.1002/glia.23229
Abstract: The regeneration of oligodendrocytes is a crucial step in recovery from demyelination, as surviving oligodendrocytes exhibit limited structural plasticity and rarely form additional myelin sheaths. New oligodendrocytes arise through the differentiation of platelet‐derived growth factor… read more here.
Keywords: induced demyelination; demyelination; matter; gray matter ... See more keywords
Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy
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DOI: 10.1002/glia.23245
Abstract: For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce demyelination, without a clear understanding of its mechanisms. LPC is an endogenous lysophospholipid so it may cause demyelination in certain diseases. We investigated whether known… read more here.
Keywords: demyelination; lipid disrupting; mechanisms lysophosphatidylcholine; lysophosphatidylcholine induced ... See more keywords
Regional oligodendrocytopathy and astrocytopathy precede myelin loss and blood–brain barrier disruption in a murine model of osmotic demyelination syndrome
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DOI: 10.1002/glia.23268
Abstract: The osmotic demyelination syndrome (ODS) is a non‐primary inflammatory disorder of the central nervous system myelin that is often associated with a precipitous rise of serum sodium concentration. To investigate the physiopathology of ODS in… read more here.
Keywords: murine model; demyelination; brain; osmotic demyelination ... See more keywords
Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped?
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DOI: 10.1002/glia.23702
Abstract: Spinal cord injury (SCI) affects over 17,000 individuals in the United States per year, resulting in sudden motor, sensory and autonomic impairments below the level of injury. These deficits may be due at least in… read more here.
Keywords: demyelination; oligodendrocyte lineage; injury; cord injury ... See more keywords
Inhibition of Piezo1 attenuates demyelination in the central nervous system
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DOI: 10.1002/glia.23722
Abstract: Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically gated ion channels are… read more here.
Keywords: demyelination; piezo1; nervous system; central nervous ... See more keywords
N-myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination.
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DOI: 10.1002/glia.24108
Abstract: The N-myc downstream regulated gene family member 1 (NDRG1) is a gene whose mutation results in peripheral neuropathy with central manifestations. While most of previous studies characterized NDRG1 role in Schwann cells, the detection of… read more here.
Keywords: demyelination; family member; downstream regulated; myc downstream ... See more keywords
TREM2‐dependent microglial function is essential for remyelination and subsequent neuroprotection
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DOI: 10.1002/glia.24335
Abstract: Disability in multiple sclerosis (MS) is driven in part by the failure of remyelination and progressive neurodegeneration. Microglia, and specifically triggering receptor expressed on myeloid cells 2 (TREM2), a factor highly expressed in microglia, have… read more here.
Keywords: neuroprotection; trem2 knockout; remyelination; trem2 dependent ... See more keywords
Nalfurafine promotes myelination in vitro and facilitates recovery from cuprizone + rapamycin‐induced demyelination in mice
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DOI: 10.1002/glia.24583
Abstract: The kappa opioid receptor has been identified as a promising therapeutic target for promoting remyelination. In the current study, we evaluated the ability of nalfurafine to promote oligodendrocyte progenitor cell (OPC) differentiation and myelination in… read more here.
Keywords: treatment; myelination; demyelination; cuprizone rapamycin ... See more keywords
Ferritin loss in astrocytes reduces spinal cord oxidative stress and demyelination in the experimental autoimmune encephalomyelitis (EAE) model
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DOI: 10.1002/glia.24616
Abstract: Demyelinating diseases such as multiple sclerosis (MS) cause myelin degradation and oligodendrocyte death, resulting in the release of toxic iron and iron‐induced oxidative stress. Astrocytes have a large capacity for iron transport and storage, however… read more here.
Keywords: spinal cord; iron; stress; oxidative stress ... See more keywords
Conventional and quantitative MRI in a novel feline model of demyelination and endogenous remyelination
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DOI: 10.1002/jmri.26300
Abstract: The feeding of irradiated food to healthy adult cats results in widespread, noninflammatory demyelination of the central nervous system (CNS); a return to a normal diet results in endogenous remyelination with functional recovery. This recently… read more here.
Keywords: demyelination; model; conventional quantitative; quantitative mri ... See more keywords