Mercury(II) binds to both of chymotrypsin's histidines, causing inhibition followed by irreversible denaturation/aggregation
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DOI: 10.1002/pro.3082
Abstract: The toxicity of mercury is often attributed to its tight binding to cysteine thiolate anions in vital enzymes. To test our hypothesis that Hg(II) binding to histidine could be a significant factor in mercury's toxic… read more here.
Keywords: aggregation; precipitation; chymotrypsin; denaturation aggregation ... See more keywords