Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2022.5370
Abstract: Key Points Question Is treatment with autologous tumor lysate-loaded dendritic cell vaccination (DCVax-L) associated with improved overall survival (OS) for patients with newly diagnosed glioblastoma (nGBM) and recurrent glioblastoma (rGBM) compared with standard of care… read more here.
Keywords: autologous tumor; tumor lysate; glioblastoma; dendritic cell ... See more keywords
Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12555
Abstract: We have previously reported that the absence of inhibins results in impaired dendritic cell (DC) maturation and function, leading to decreased T cell activation and diminished delayed‐type hypersensitivity responses. Here, we investigated the role of… read more here.
Keywords: regulatory cell; induction; function; cell ... See more keywords
3D‐Printed Dendritic Cell Vaccines for Post‐Surgery Cancer Immunotherapy
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DOI: 10.1002/adfm.202400507
Abstract: Dendritic cell (DC) vaccines have shown promising effects in cancer management, while low cell activity and low migration rate to lymph nodes limit their clinical application. Here, this work reports a bioink DC vaccine, synthesized… read more here.
Keywords: cancer; dendritic cell; cancer immunotherapy; cell ... See more keywords
Antigen‐Free Radionuclide‐Embedded Gold Nanoparticles for Dendritic Cell Maturation, Tracking, and Strong Antitumor Immunity
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201701369
Abstract: Dendritic cell (DC)-based cancer immunotherapy requires efficient maturation of DCs and sensitive monitoring of DCs localized in the lymph nodes that activate T cells. This paper reports a robust and simple surface chemistry for highly… read more here.
Keywords: embedded gold; dcs; chemistry; maturation ... See more keywords
Ovalbumin and Poly(i:c) Encapsulated Dendritic Cell‐Targeted Nanoparticles for Immune Activation in the Small Intestinal Lymphatic System
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200909
Abstract: Here, antigen and adjuvant encapsulated dendritic cell‐targeted nanoparticles for immune activation in the small intestinal lymphatic system to inhibit melanoma development are described. This strategy is demonstrated using chondroitin sulfate‐coated nanoparticles (OPGMN) grafted with glycocholic… read more here.
Keywords: cell; cell targeted; nanoparticles immune; dendritic cell ... See more keywords
A Bidirectional Single‐Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204544
Abstract: Dendritic cell (DC) migration is a fundamental step during execution of its adaptive immunity functions. Studying DC migration characteristics is critical for development of DC‐dependent allergy treatments, vaccines, and cancer immunotherapies. Here, a microfluidics‐based single‐cell… read more here.
Keywords: cell; dendritic cell; retrieval; single cell ... See more keywords
Biomaterials Facilitating Dendritic Cell-Mediated Cancer Immunotherapy.
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DOI: 10.1002/advs.202301339
Abstract: Dendritic cell (DC)-based cancer immunotherapy has exhibited remarkable clinical prospects because DCs play a central role in initiating and regulating adaptive immune responses. However, the application of traditional DC-mediated immunotherapy is limited due to insufficient… read more here.
Keywords: immunotherapy; mediated cancer; dendritic cell; cancer ... See more keywords
Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast-Dendritic Cell Crosstalk in Atopic Dermatitis.
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DOI: 10.1002/advs.202501670
Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease driven by immune dysregulation and Th2‐dominant inflammation. This study identifies phosphodiesterase 4D (PDE4D) as a key regulator of AD pathogenesis and a potential therapeutic target. Single‐cell… read more here.
Keywords: cell; atopic dermatitis; fibroblast dendritic; dendritic cell ... See more keywords
Overcoming EGFR-Mediated Dendritic Cell Dysfunction to Enhance Anti-tumor Immunity in EGFR-Mutant NSCLC by Precisely Targeting CD73 With pH-responsive Nanocarriers.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202513182
Abstract: EGFR mutations remain a major challenge in immunotherapy for non‐small cell lung cancer (NSCLC), with poor responses to immune checkpoint inhibitors driven by mechanisms associated with EGFR mutation‐mediated tumor microenvironment (TME) modulation. This study reveals… read more here.
Keywords: mutant nsclc; dendritic cell; tumor; cell ... See more keywords
Heterologous SARS‐CoV‐2 vaccinations in patients with B‐cell lymphoid malignancies
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26418
Abstract: or decitabine in blast-phase myeloproliferative neoplasm: a multicenter series of 32 consecutive cases. Am J Hematol. 2021;96:781-789. 13. DiNardo CD, Jonas BA, Pullarkat V, et al. Azacitidine and venetoclax in previously untreated acute myeloid leukemia.… read more here.
Keywords: dendritic cell; cell neoplasm; blastic plasmacytoid; plasmacytoid dendritic ... See more keywords
Dendritic cell vaccines improve the glioma microenvironment: Influence, challenges, and future directions
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DOI: 10.1002/cam4.5511
Abstract: Gliomas, especially the glioblastomas, are one of the most aggressive intracranial tumors with poor prognosis. This might be explained by the heterogeneity of tumor cells and the inhibitory immunological microenvironment. Dendritic cells (DCs), as the… read more here.
Keywords: microenvironment; dendritic cell; vaccines improve; glioma microenvironment ... See more keywords