Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2022.5370
Abstract: Key Points Question Is treatment with autologous tumor lysate-loaded dendritic cell vaccination (DCVax-L) associated with improved overall survival (OS) for patients with newly diagnosed glioblastoma (nGBM) and recurrent glioblastoma (rGBM) compared with standard of care… read more here.
Keywords: autologous tumor; tumor lysate; glioblastoma; dendritic cell ... See more keywords
Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12555
Abstract: We have previously reported that the absence of inhibins results in impaired dendritic cell (DC) maturation and function, leading to decreased T cell activation and diminished delayed‐type hypersensitivity responses. Here, we investigated the role of… read more here.
Keywords: regulatory cell; induction; function; cell ... See more keywords
Antigen‐Free Radionuclide‐Embedded Gold Nanoparticles for Dendritic Cell Maturation, Tracking, and Strong Antitumor Immunity
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201701369
Abstract: Dendritic cell (DC)-based cancer immunotherapy requires efficient maturation of DCs and sensitive monitoring of DCs localized in the lymph nodes that activate T cells. This paper reports a robust and simple surface chemistry for highly… read more here.
Keywords: embedded gold; dcs; chemistry; maturation ... See more keywords
Ovalbumin and Poly(i:c) Encapsulated Dendritic Cell‐Targeted Nanoparticles for Immune Activation in the Small Intestinal Lymphatic System
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200909
Abstract: Here, antigen and adjuvant encapsulated dendritic cell‐targeted nanoparticles for immune activation in the small intestinal lymphatic system to inhibit melanoma development are described. This strategy is demonstrated using chondroitin sulfate‐coated nanoparticles (OPGMN) grafted with glycocholic… read more here.
Keywords: cell; cell targeted; nanoparticles immune; dendritic cell ... See more keywords
A Bidirectional Single‐Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration
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DOI: 10.1002/advs.202204544
Abstract: Dendritic cell (DC) migration is a fundamental step during execution of its adaptive immunity functions. Studying DC migration characteristics is critical for development of DC‐dependent allergy treatments, vaccines, and cancer immunotherapies. Here, a microfluidics‐based single‐cell… read more here.
Keywords: cell; dendritic cell; retrieval; single cell ... See more keywords
Biomaterials Facilitating Dendritic Cell-Mediated Cancer Immunotherapy.
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DOI: 10.1002/advs.202301339
Abstract: Dendritic cell (DC)-based cancer immunotherapy has exhibited remarkable clinical prospects because DCs play a central role in initiating and regulating adaptive immune responses. However, the application of traditional DC-mediated immunotherapy is limited due to insufficient… read more here.
Keywords: immunotherapy; mediated cancer; dendritic cell; cancer ... See more keywords
Heterologous SARS‐CoV‐2 vaccinations in patients with B‐cell lymphoid malignancies
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26418
Abstract: or decitabine in blast-phase myeloproliferative neoplasm: a multicenter series of 32 consecutive cases. Am J Hematol. 2021;96:781-789. 13. DiNardo CD, Jonas BA, Pullarkat V, et al. Azacitidine and venetoclax in previously untreated acute myeloid leukemia.… read more here.
Keywords: dendritic cell; cell neoplasm; blastic plasmacytoid; plasmacytoid dendritic ... See more keywords
Dendritic cell vaccines improve the glioma microenvironment: Influence, challenges, and future directions
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DOI: 10.1002/cam4.5511
Abstract: Gliomas, especially the glioblastomas, are one of the most aggressive intracranial tumors with poor prognosis. This might be explained by the heterogeneity of tumor cells and the inhibitory immunological microenvironment. Dendritic cells (DCs), as the… read more here.
Keywords: microenvironment; dendritic cell; vaccines improve; glioma microenvironment ... See more keywords
Blastic plasmacytoid dendritic cell neoplasm (BPDCN): A promising future in the era of targeted therapeutics
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DOI: 10.1002/cncr.34345
Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy arising from precursor dendritic cells. BPDCN cells characteristically express several markers on their cell surfaces including CD123, CD4, and CD56. Because of its rarity… read more here.
Keywords: cell; dendritic cell; plasmacytoid dendritic; treatment ... See more keywords
OMIP‐44: 28‐Color Immunophenotyping of the Human Dendritic Cell Compartment
Sign Up to like & getrecommendations! Published in 2019 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23854
Abstract: This work describes the first 30-parameter immunophenotyping of the human dendritic cell (DC) compartment using fluorescent-based flow cytometry. The optimized panel allows for simultaneous detection of 21 myeloid-centric markers distinguishing all canonical DC subsets, with… read more here.
Keywords: immunophenotyping human; human dendritic; cell compartment; dendritic cell ... See more keywords
Erythrocyte lysing solutions have a detrimental effect in flow cytometric dendritic cell detection
Sign Up to like & getrecommendations! Published in 2022 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24696
Abstract: Flow cytometry (FCM) enumeration of peripheral blood dendritic cells (PBDCs) is a minimally invasive procedure extremely useful for immunological studies. Numbers of PBDCs vary depending on age, lifestyle, or in pathologies like cancer, leukemia or… read more here.
Keywords: cell; lysing solutions; detrimental effect; dendritic cell ... See more keywords