Surface engineered polymersomes for enhanced modulation of dendritic cells during cardiovascular immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced functional materials"
DOI: 10.1002/adfm.201904399
Abstract: The principle cause of cardiovascular disease (CVD) is atherosclerosis, a chronic inflammatory condition characterized by immunologically complex fatty lesions within the intima of arterial vessel walls. Dendritic cells (DCs) are key regulators of atherosclerotic inflammation,… read more here.
Keywords: dcs; surface; dendritic cells; engineered polymersomes ... See more keywords
A 3D Macroporous Alginate Graphene Scaffold with an Extremely Slow Release of a Loaded Cargo for In Situ Long-Term Activation of Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201800571
Abstract: Ex vivo manipulation of autologous antigen-presenting cells and their subsequent infusion back into the patient to dictate immune response is one of the promising strategies in cancer immunotherapy. Here, a 3D alginate scaffold embedded with… read more here.
Keywords: term; long term; slow release; dendritic cells ... See more keywords
Extracellular Trap-Mimicking DNA-Histone Mesostructures Synergistically Activate Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900926
Abstract: Extracellular traps (ETs), such as neutrophil extracellular traps, are a physical mesh deployed by immune cells to entrap and constrain pathogens. ETs are immunogenic structures composed of DNA, histones, and an array of variable protein… read more here.
Keywords: extracellular trap; dna; dna histone; dendritic cells ... See more keywords
Soluble and Microparticle-Based Delivery of TLR4 and TLR9 Agonists Differentially Modulate 3D Chemotaxis of Bone Marrow-Derived Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001899
Abstract: Vaccines are commonly administered subcutaneously or intramuscularly, and local immune cells, notably dendritic cells (DCs), play a significant role in transporting vaccine antigens and adjuvants to draining lymph nodes. Here, it is compared how soluble… read more here.
Keywords: delivery; modulate chemotaxis; dendritic cells; cpg ... See more keywords
Expandable Immunotherapeutic Nanoplatforms Engineered from Cytomembranes of Hybrid Cells Derived from Cancer and Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201900499
Abstract: Using the cytomembranes (FMs) of hybrid cells acquired from the fusion of cancer and dendritic cells (DCs), this study offers a biologically derived platform for the combination of immunotherapy and traditional oncotherapy approaches. Due to… read more here.
Keywords: cancer dendritic; expandable immunotherapeutic; hybrid cells; dendritic cells ... See more keywords
Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202101190
Abstract: The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biomaterials development mimicking natural antigen-presenting cells (APCs) for T-cell expansion. In contrast to conventional bottom-up approaches aimed at layering synthetic… read more here.
Keywords: intracellular hydrogelation; dendritic cells; antigen; antigen presenting ... See more keywords
A Polyvalent Peptide CD40 Nanoagonist for Targeted Modulation of Dendritic Cells and Amplified Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202109432
Abstract: Targeted immunomodulation through biomolecule‐based nanostructures, especially to dendritic cells (DCs), holds great promise for effective cancer therapy. However, construction of high‐performance agonist by mimicking natural ligand to activate immune cell signaling is a great challenge… read more here.
Keywords: pva cd40; polyvalent peptide; cd40; dendritic cells ... See more keywords
Aggregation‐Induced‐Emission Photosensitizer‐Loaded Nano‐Superartificial Dendritic Cells with Directly Presenting Tumor Antigens and Reversed Immunosuppression for Photodynamically Boosted Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202208555
Abstract: The success of tumor immunotherapy highlights the potential of harnessing immune system to fight cancer. Activating both native T cells and exhausted T cells is a critical step for generating effective antitumor immunity, which is… read more here.
Keywords: superartificial dendritic; induced emission; aggregation induced; tumor antigens ... See more keywords
Hypoxia promotes the tolerogenic phenotype of plasmacytoid dendritic cells in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4511
Abstract: We aim to review the roles of plasmacytoid dendritic cells (pDCs) in head and neck squamous cell carcinoma (HNSCC) and explore the effects of hypoxia on the tolerogenic transformation of pDCs. read more here.
Keywords: cell carcinoma; head neck; neck squamous; squamous cell ... See more keywords
A Synthetic MUC1 Anticancer Vaccine Containing Mannose Ligands for Targeting Macrophages and Dendritic Cells
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DOI: 10.1002/cmdc.201700646
Abstract: A MUC1 anticancer vaccine equipped with covalently linked divalent mannose ligands was found to improve the antigen uptake and presentation by targeting mannose‐receptor‐positive macrophages and dendritic cells. It induced much stronger specific IgG immune responses… read more here.
Keywords: anticancer vaccine; mannose ligands; dendritic cells; macrophages dendritic ... See more keywords
Actions of Dendritic Cells in the Kidney during Hypertension.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210050
Abstract: The immune response plays a critical role in the pathogenesis of hypertension, and immune cell populations can promote blood pressure elevation via actions in the kidney. Among these cell lineages, dendritic cells (DCs), the most… read more here.
Keywords: cell; blood pressure; dendritic cells; hypertension ... See more keywords