A Dendritic Polymer‐Based Nanosystem Mediates Drug Penetration and Irreversible Endoplasmic Reticulum Stresses in Tumor via Neighboring Effect
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DOI: 10.1002/adma.202201200
Abstract: Nanoparticles (NPs)‐based cancer therapeutics are generally impeded by poor drug penetration into solid tumors due to their dense tumor extracellular matrix (ECM). Herein, pH/redox‐responsive dendritic polymer‐based NPs are developed to amplify the neighboring effect for… read more here.
Keywords: effect; penetration; dendritic polymer; neighboring effect ... See more keywords
Targeted Drug/Gene/Photodynamic Therapy via a Stimuli‐Responsive Dendritic‐Polymer‐Based Nanococktail for Treatment of EGFR‐TKI‐Resistant Non‐Small‐Cell Lung Cancer
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DOI: 10.1002/adma.202201516
Abstract: Yes‐associated protein (YAP) has been identified as a key driver for epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) resistance. Inhibition of YAP expression could be a potential therapeutic option for treating non‐small‐cell lung cancer (NSCLC).… read more here.
Keywords: cell; egfr tki; therapy; dendritic polymer ... See more keywords