Estrous cycle impacts on dendritic spine plasticity in rat nucleus accumbens core and shell and caudate–putamen
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25460
Abstract: An important factor that can modulate neuron properties is sex‐specific hormone fluctuations, including the human menstrual cycle and rat estrous cycle in adult females. Considering the striatal brain regions, the nucleus accumbens (NAc) core, NAc… read more here.
Keywords: estrous cycle; nac shell; cycle; dendritic spine ... See more keywords
SHANK1 is differentially expressed during development in CA1 hippocampal neurons and astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22564
Abstract: Recent studies have strongly suggested a role for the synaptic scaffolding protein SHANK1 in normal synaptic structure and signaling. Global SHANK1 knockout (SHANK1−/−) mice demonstrate reduced dendritic spine density, an immature dendritic spine phenotype and… read more here.
Keywords: dendritic spine; expression; differentially expressed; shank1 ... See more keywords
Acute MPTP treatment decreases dendritic spine density of striatal medium spiny neurons via SNK‐SPAR pathway in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22249
Abstract: Parkinson's disease (PD) is a well‐known neurodegenerative disorder associated with a high risk in middle‐aged and elderly individuals, severely impacting the patient's quality of life. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) is frequently used to establish PD in animals.… read more here.
Keywords: dendritic spine; mptp; density striatal; spine density ... See more keywords
Optimisation of ketamine‐xylazine anaesthetic dose and its association with changes in the dendritic spine of CA1 hippocampus in the young and old male and female Wistar rats
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.936
Abstract: Abstract Background A combination of ketamine‐xylazine (K‐X) is frequently used for anaesthesia in rats. Sex and age affect this cocktail dosage. Ketamine causes a hypnotic effect by blocking NMDA receptors located on the dendritic spine… read more here.
Keywords: ketamine xylazine; spine ca1; spine; dendritic spine ... See more keywords
Increases in dendritic spine density in BLA without metabolic changes in a rodent model of PTSD
Sign Up to like & getrecommendations! Published in 2019 at "Brain Structure and Function"
DOI: 10.1007/s00429-019-01943-4
Abstract: Imaging studies have shown abnormal amygdala function in patients with posttraumatic stress disorder (PTSD). In addition, alterations in synaptic plasticity have been associated with psychiatric disorders and previous reports have indicated alterations in the amygdala… read more here.
Keywords: density bla; model ptsd; dendritic spine; bla ... See more keywords
EphB2 activates CREB-dependent expression of Annexin A1 to regulate dendritic spine morphogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.11.011
Abstract: Dendritic spines are the postsynaptic structure to mediate signal transduction in neural circuitry, whose function and plasticity are regulated by organization of their molecular architecture and by the expression of target genes and proteins. EphB2,… read more here.
Keywords: dendritic spine; annexin; expression; spine morphogenesis ... See more keywords
706. Wnt/β-Catenin Pathway Contributions to Dendritic Spine and Glutamatergic Synapse Formation Responsive to Lithium-Mediated GSK3 Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.02.773
Abstract: Background A major direct target of lithium is the metalloenzyme GSK3, the central kinase in the Wnt/β-catenin pathway broadly involved in neural development. Methods We have investigated neurodevelopmental and behavioral functions of DIXDC1, which regulates… read more here.
Keywords: dendritic spine; catenin pathway; lithium; wnt catenin ... See more keywords
Electroconvulsive seizures influence dendritic spine morphology and BDNF expression in a neuroendocrine model of depression
Sign Up to like & getrecommendations! Published in 2018 at "Brain Stimulation"
DOI: 10.1016/j.brs.2018.04.003
Abstract: BACKGROUND Electroconvulsive therapy (ECT) is a rapid and effective treatment for major depressive disorder. Chronic stress-induced depression causes dendrite atrophy and deficiencies in brain-derived neurotrophic factor (BDNF), which are reversed by anti-depressant drugs. Electroconvulsive seizures… read more here.
Keywords: electroconvulsive seizures; depression; dendritic spine; morphology ... See more keywords
CNS Neurons Deposit Laminin α5 to Stabilize Synapses
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.028
Abstract: SUMMARY Synapses in the developing brain are structurally dynamic but become stable by early adulthood. We demonstrate here that an α5-subunit-containing laminin stabilizes synapses during this developmental transition. Hippocampal neurons deposit laminin α5 at synapses… read more here.
Keywords: neurons deposit; dendritic spine; stabilize synapses; laminin stabilize ... See more keywords
Dendritic spine loss caused by AlCl3 is associated with inhibition of the Rac 1/cofilin signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.09.145
Abstract: Aluminum (Al) has neurotoxicity that can result in cognitive dysfunction. Hippocampal dendritic spine loss is a pathological characteristic of cognitive dysfunction. Our previous study reported that Al exposure caused dendritic spine loss in the hippocampus,… read more here.
Keywords: dendritic spine; spine loss; rac cofilin;
CRMP2 improves memory deficits by enhancing the maturation of neuronal dendritic spines after traumatic brain injury
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113253
Abstract: Our recent study investigated the role of collapsin response mediator protein-2 (CRMP2) on dendritic spine morphology and memory function after traumatic brain injury (TBI). First, we examined the density and morphology of dendritic spines in… read more here.
Keywords: dendritic spine; crmp2; density; type ... See more keywords