Dendritic spines provide cognitive resilience against Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Neurology"
DOI: 10.1002/ana.25049
Abstract: Neuroimaging and other biomarker assays suggest that the pathological processes of Alzheimer's disease (AD) begin years prior to clinical dementia onset. However, some 30 to 50% of older individuals who harbor AD pathology do not… read more here.
Keywords: alzheimer disease; cognitive resilience; dendritic spines; pathology ... See more keywords
Diolistic Labeling and Analysis of Dendritic Spines.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7571-6_14
Abstract: Dendritic spines are diverse and plastic components of the neuronal cell apparatus and are highly responsive to trophic factors during both development and adulthood. Diolistic labeling of neurons with lipophilic fluorescent dyes, coupled with advanced… read more here.
Keywords: microscopy; diolistic labeling; analysis dendritic; labeling analysis ... See more keywords
Insights into age-old questions of new dendritic spines: From form to function
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2016.07.014
Abstract: Principal neurons in multiple brain regions receive a vast majority of excitatory synaptic contacts on the tiny dendritic appendages called dendritic spines. These structures are believed to be the locus of memory storage in the… read more here.
Keywords: insights age; old questions; age old; function ... See more keywords
Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.02.004
Abstract: The posttranslational modifications of CRMP2 play an important role in axon outgrowth, cell polarization and dendritic morphogenesis. However, whether CRMP2 and its posttranslational modifications are involved in dendritic spine development specifically is not completely clear.… read more here.
Keywords: crmp2; formation; formation maturation; maturation dendritic ... See more keywords
Imaging dendritic spines: molecular organization and signaling for plasticity
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2020.08.006
Abstract: The structural plasticity of dendritic spines is considered to be essential for various forms of synaptic plasticity and, ultimately, learning and memory. The process is mediated by signaling pathways that promote the reorganization of the… read more here.
Keywords: molecular organization; imaging dendritic; spines molecular; plasticity ... See more keywords
Structural LTP: Signal transduction, actin cytoskeleton reorganization, and membrane remodeling of dendritic spines
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2022.102534
Abstract: Induction of long-term synaptic potentiation (LTP) in excitatory neurons triggers a transient enlargement of dendritic spines followed by decay to sustained size expansion, a process termed structural LTP which contributes to the cellular basis of… read more here.
Keywords: cytoskeleton reorganization; actin cytoskeleton; membrane; dendritic spines ... See more keywords
Adolescent pruning and stabilization of dendritic spines on cortical layer 5 pyramidal neurons do not depend on gonadal hormones
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Cognitive Neuroscience"
DOI: 10.1016/j.dcn.2018.01.007
Abstract: Highlights • Spines in frontal cortex of female mice are pruned and stabilized during adolescence.• Pre-pubertal hormone exposure does not accelerate spine pruning and stabilization.• Pre-pubertal gonadectomy does not prevent spine pruning and stabilization.• Pre-pubertal… read more here.
Keywords: pre pubertal; stabilization; pruning stabilization; adolescent pruning ... See more keywords
CRMP2 improves memory deficits by enhancing the maturation of neuronal dendritic spines after traumatic brain injury
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113253
Abstract: Our recent study investigated the role of collapsin response mediator protein-2 (CRMP2) on dendritic spine morphology and memory function after traumatic brain injury (TBI). First, we examined the density and morphology of dendritic spines in… read more here.
Keywords: dendritic spine; crmp2; density; type ... See more keywords
The activation of NMDA receptors alters the structural dynamics of the spines of hippocampal interneurons
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.08.042
Abstract: N-Methyl-d-Aspartate receptors (NMDARs) are present in both pyramidal neurons and interneurons of the hippocampus. These receptors play a key role in the structural plasticity of excitatory neurons, but to date little is known about their… read more here.
Keywords: dynamics spines; somatostatin expressing; activation nmda; structural dynamics ... See more keywords
Open Up to Make New Contacts: Caldendrin Senses Postsynaptic Calcium Influx to Dynamically Organize Dendritic Spines
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.02.021
Abstract: In this issue of Neuron, Mikhaylova et al. (2018) report how the Ca2+ sensor caldendrin interacts in dendritic spines with cortactin to control actin remodeling. Combining molecular and functional approaches, this work gains insights into postsynaptic… read more here.
Keywords: new contacts; open make; make new; caldendrin senses ... See more keywords
Exploring the Dendritic Spine Pathology in a Schizophrenia-related Neurodevelopmental Animal Model
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.11.006
Abstract: Schizophrenia is a neurodevelopmental disorder identified by psychotic episodes, as well as cognitive deficits. There are reports of multiple alterations in the brain in schizophrenia, such as fewer dendritic spines with shape abnormalities in cortical… read more here.
Keywords: schizophrenia; spine pathology; dendritic spine; pathology ... See more keywords