Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21937
Abstract: Dendrobine has potential advantages in suppressing atherosclerosis (AS). FK506‐binding protein 1A (FKBP1A) is implicated in the regulation of autophagy, inflammation, and apoptosis. To reveal the mechanism by which dendrobine inhibits AS by modulating autophagy, oxidative… read more here.
Keywords: dendrobine; apoptosis; oxidative stress; senescence ... See more keywords
Two new alkaloids from Dendrobium nobile Lindl. exhibited neuroprotective activity, and dendrobine alleviated Aβ1−42‐induced apoptosis by inhibiting CDK5 activation in PC12 cells
Sign Up to like & getrecommendations! Published in 2023 at "Drug Development Research"
DOI: 10.1002/ddr.22030
Abstract: Dendrobium nobile Lindl. is registered in the Chinese Pharmacopoeia as a traditional medicine. Phytochemical investigation of the ethanol extract of D. nobile Lindl. stems yielded three alkaloid compounds, including two new compounds dendroxine B (2)… read more here.
Keywords: dendrobine; pc12 cells; nobile lindl; induced apoptosis ... See more keywords
Metabolic characterization of a potent natural neuroprotective agent dendrobine in vitro and in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00690-9
Abstract: Dendrobine is the main sesquiterpene alkaloid of Dendrobium nobile Lindl, which exhibits potent neuroprotective activity. However, its metabolism and disposition are little known. In this study, we investigated the metabolic characteristics of dendrobine in vitro… read more here.
Keywords: dendrobine; metabolism; vitro rats; rats metabolic ... See more keywords
Unveiling the potential of dendrobine: insights into bioproduction, bioactivities, safety, circular economy, and future prospects
Sign Up to like & getrecommendations! Published in 2025 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2024.2438161
Abstract: Abstract This comprehensive review aims to explore and consolidate the current knowledge on dendrobine, including its biological activities, molecular mechanisms of action, effects on various physiological processes, potential toxicity, and safety considerations, in order to… read more here.
Keywords: dendrobine also; dendrobine; circular economy; bioproduction ... See more keywords
Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1956672
Abstract: Dendrobine has been reported to reduce blood lipid levels and apoptosis. The present study was designed to observe the effect of dendrobine in a model of ERS using vascular endothelial cells and to reveal the… read more here.
Keywords: caspase; apoptosis; dendrobine; mir 381 ... See more keywords
Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1616070
Abstract: Background In early postmenopausal women with sex steroid deficiency, an imbalance between bone resorption and bone formation causes an accelerated decline in bone mineral density due to a longer lifespan of osteoclasts and a shorter… read more here.
Keywords: dendrobine; catenin; postmenopausal osteoporosis; bone formation ... See more keywords