A Transformable Amphiphilic and Block Polymer−Dendron Conjugate for Enhanced Tumor Penetration and Retention with Cellular Homeostasis Perturbation via Membrane Flow
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202200048
Abstract: Efficient penetration and retention of therapeutic agents in tumor tissues can be realized through rational design of drug delivery systems. Herein, a polymer−dendron conjugate, POEGMA‐b‐p(GFLG‐Dendron‐Ppa) (GFLG‐DP), is presented, which allows a cathepsin‐B‐triggered stealthy‐to‐sticky structural transformation.… read more here.
Keywords: penetration retention; tumor; dendron; membrane ... See more keywords
Assembly of High-Potency Photosensitizer-Antibody Conjugates through Application of Dendron Multiplier Technology.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00678
Abstract: Exploitation of photosensitizers as payloads for antibody-based anticancer therapeutics offers a novel alternative to the small pool of commonly utilized cytotoxins. However, existing bioconjugation methodologies are incompatible with the requirement of increased antibody loading without… read more here.
Keywords: dendron; assembly high; antibody; multiplier ... See more keywords
Photoresponsive Polypeptide-Glycosylated Dendron Amphiphiles: UV-Triggered Polymersomes, OVA Release, and In Vitro Enhanced Uptake and Immune Response.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c01465
Abstract: Efficient therapeuic proteins' delivery into mammalian cells and subcellular transport (e.g., fast escape from endolysosomes into cytoplasm) are two key biological barriers that need to be overcome for antigen-based immunotherapy and related biomedical applications. For… read more here.
Keywords: ova release; photoresponsive polypeptide; dendron; polypeptide glycosylated ... See more keywords
Comparison of MRI Properties between Multimeric DOTAGA and DO3A Gadolinium-Dendron Conjugates.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b01747
Abstract: The inherent lack of sensitivity of MRI needs the development of new Gd contrast agents in order to extend the application of this technique to cellular imaging. For this purpose, two multimeric MR contrast agents… read more here.
Keywords: comparison mri; dendron; properties multimeric; do3a ... See more keywords
Mechanisms underlying interactions between PAMAM dendron-grafted surfaces with DPPC membranes
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra03742f
Abstract: Biofouling is a pervasive problem which demands the creation of smart, antifouling surfaces. Towards this end, we examine the interactions between a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer and a polyamidoamine (PAMAM) dendron-grafted surface. In addition, we… read more here.
Keywords: dendron; pamam dendron; dendron generation; mechanisms underlying ... See more keywords
Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d0bm01813a
Abstract: For the establishment of advanced medicines such as cancer immunotherapy, high performance carriers that precisely deliver biologically active molecules must be developed to target organelles of the cells and to release their contents there. From… read more here.
Keywords: dendron lipid; dendron; lipid based; sensitive dendron ... See more keywords
Decorating an anisotropic Au13 core with dendron thiolates: enhancement of optical absorption and photoluminescence.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc05235g
Abstract: We successfully introduced up to 12 poly(benzyl ether)dendron-thiols of the second generation (D2SH) into the Au13 core of [Au23(ScC6H11)16]- while retaining the geometric structure. The decoration with D2SH enhanced the optical absorbance in the >2.5… read more here.
Keywords: au13 core; photoluminescence; dendron; decorating anisotropic ... See more keywords
Robust GABAergic Regulation of the GnRH Neuron Distal Dendron
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac194
Abstract: Abstract The amino acid transmitter γ-aminobutyric acid (GABA) is suspected to play an important role in regulating the activity of the gonadotropin-releasing hormone (GnRH) neurons controlling fertility. Rodent GnRH neurons have a novel dendritic compartment… read more here.
Keywords: distal dendron; dendron; neuron distal; regulation ... See more keywords
Polyamidoamine Dendron-Bearing Lipids as Drug-Delivery Excipients
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27227817
Abstract: An amine-terminated polyamidoamine (PAMAM) dendron and two long alkyl groups were designed as a novel drug carrier that possesses an interior for the encapsulation of drugs and a biocompatible surface. We synthesized three dendron-bearing lipids,… read more here.
Keywords: dendron bearing; dendron; pamam; drug ... See more keywords