Controversy and debate on dengue vaccine series-paper 1: review of a licensed dengue vaccine: inappropriate subgroup analyses and selective reporting may cause harm in mass vaccination programs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2017.11.019
Abstract: Severe life-threatening dengue fever usually occurs when a child is infected by dengue virus a second time. This is caused by a phenomenon called antibody-dependent enhancement (ADE). Since dengue vaccines can mimic a first infection… read more here.
Keywords: vaccination programs; mass vaccination; dengue; vaccine ... See more keywords
Biodistribution and safety of a live attenuated tetravalent dengue vaccine in the cynomolgus monkey.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.08.071
Abstract: BACKGROUND The first licensed dengue vaccine is a recombinant, live, attenuated, tetravalent dengue virus vaccine (CYD-TDV; Sanofi Pasteur). This study assessed the biodistribution, shedding, and toxicity of CYD-TDV in a non-human primate model as part… read more here.
Keywords: cyd tdv; live attenuated; vaccine; attenuated tetravalent ... See more keywords
Biased efficacy estimates in phase-III dengue vaccine trials due to heterogeneous exposure and differential detectability of primary infections across trial arms
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DOI: 10.1371/journal.pone.0210041
Abstract: Vaccine efficacy (VE) estimates are crucial for assessing the suitability of dengue vaccine candidates for public health implementation, but efficacy trials are subject to a known bias to estimate VE toward the null if heterogeneous… read more here.
Keywords: heterogeneous exposure; exposure; efficacy; vaccine ... See more keywords
Exploring the role of a recently licensed dengue vaccine in Australian travellers
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DOI: 10.5694/mja2.50471
Abstract: Dengue has a significant impact on global health and is a leading cause of illness in travellers who visit dengue endemic countries. There are four serotypes of dengue virus, belonging to the Flaviviridae family, that… read more here.
Keywords: dengue virus; infection; dengue; virus ... See more keywords