Nickel-Catalyzed, Manganese-Assisted Denitrogenative Cross-Electrophile-Coupling of Benzotriazinones with Alkyl Halides for ortho-Alkylated Benzamides.
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DOI: 10.1021/acs.orglett.2c02182
Abstract: A nickel-catalyzed denitrogenative cross-electrophile-coupling of benzotriazinones with unactivated alkyl halides (X = Cl, Br, I) in the presence of manganese powder as a reductant has been developed. The reaction furnishes ortho-alkylated secondary benzamides in modest… read more here.
Keywords: ortho alkylated; denitrogenative cross; nickel catalyzed; electrophile coupling ... See more keywords
Nickel-Catalyzed Denitrogenative Cross-Coupling Reaction of 1,2,3-Benzotriazin-4(3 H)-ones with Organoboronic Acids: An Easy Access to Ortho-Arylated and Alkenylated Benzamides.
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DOI: 10.1021/acs.orglett.8b01401
Abstract: A novel nickel-catalyzed approach to synthesize ortho-arylated and alkenylated benzamides in good to high yields via a denitrogenative cross-coupling reaction of 1,2,3-benzotriazin-4(3 H)-ones with organoboronic acids is described. The reaction proceeds through a five-membered azanickelacyclic… read more here.
Keywords: ortho arylated; arylated alkenylated; denitrogenative cross; alkenylated benzamides ... See more keywords