Regression of fibrous dysplasia in response to denosumab therapy: A report of two cases
Sign Up to like & getrecommendations! Published in 2021 at "Bone Reports"
DOI: 10.1016/j.bonr.2021.101058
Abstract: We present two patients with fibrous dysplasia who showed a decrease in lesional size and activity after denosumab therapy. Both patients also experienced a reduction in pain and bone turnover markers, which had not been… read more here.
Keywords: regression fibrous; denosumab therapy; fibrous dysplasia; dysplasia ... See more keywords
Preoperative Denosumab Therapy Against Giant Cell Tumor of Bone is Associated with an Increased Risk of Local Recurrence After Curettage Surgery
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-022-11411-9
Abstract: Denosumab has been shown to be highly effective at suppressing the progression of giant cell tumor of bone (GCTB). However, recent studies have observed a potential increased risk of local recurrence after surgery following the… read more here.
Keywords: preoperative denosumab; increased risk; local recurrence; surgery ... See more keywords
Effects of zoledronate on bone mineral density and bone turnover after long-term denosumab therapy: Observations in a real-world setting.
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DOI: 10.2139/ssrn.4106277
Abstract: BACKGROUND The rebound effect after denosumab discontinuation is lessened with subsequent zoledronate therapy. However, it is unclear whether this mitigation is sufficient after long-term denosumab treatment. OBJECTIVE This retrospective observational study analysed bone mineral density… read more here.
Keywords: long term; denosumab therapy; bone; therapy ... See more keywords
Does the VDR gene polymorphism influence the efficacy of denosumab therapy in postmenopausal osteoporosis?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1063762
Abstract: Introduction One of the challenges of personalized medicine is a departure from traditional pharmacology toward individualized, genotype-based therapies. Postmenopausal osteoporosis is a prevalent condition requiring intensive treatment, whose effects are measurable only after a long… read more here.
Keywords: vdr gene; denosumab therapy; gene; polymorphism ... See more keywords
Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor
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DOI: 10.3892/ol.2017.6655
Abstract: Although denosumab has been reported to induce effective clinical results with respect to tumor shrinkage in a short-term follow-up clinical study, total spondylectomy is recognized as the treatment of choice for eradicating giant cell tumors… read more here.
Keywords: giant cell; bloc; denosumab therapy; thoracic vertebra ... See more keywords