Preoperative denosumab treatment in patients with giant cell bone tumors in limbs: A retrospective study using propensity score matching.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5870
Abstract: BACKGROUND AND OBJECTIVES Denosumab is recommended for advanced giant cell tumor of bone (GCTB) that is unresectable or resectable with unacceptable morbidity. But the effect of preoperative denosumab treatment on the local control GCTB remains… read more here.
Keywords: preoperative denosumab; denosumab treatment; group; control ... See more keywords
Denosumab treatment for giant-cell tumor of bone: a systematic review of the literature
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Orthopaedic and Trauma Surgery"
DOI: 10.1007/s00402-019-03167-x
Abstract: BackgroundDenosumab is a human monoclonal antibody (mAb) that specifically inhibits tumor-associated bone lysis through the RANKL pathway and has been used as neoadjuvant therapy for giant-cell tumor of bone (GCTB) in surgical as well as… read more here.
Keywords: giant cell; cell tumor; treatment; denosumab treatment ... See more keywords
Comparison of Romosozumab Versus Denosumab Treatment on Bone Mineral Density After One Year in Rheumatoid Arthritis Patients with Severe Osteoporosis: A Randomized Clinical Pilot Study.
Sign Up to like & getrecommendations! Published in 2022 at "Modern rheumatology"
DOI: 10.1093/mr/roac059
Abstract: OBJECTIVES To investigate the effect of romosozumab versus denosumab treatment on bone mineral density (BMD), disease activity, and joint damage in patients with rheumatoid arthritis (RA) and severe osteoporosis. METHODS Fifty-one postmenopausal women were enrolled… read more here.
Keywords: denosumab treatment; denosumab; versus denosumab; treatment bone ... See more keywords
Successful treatment with denosumab for pelvic fibrous dysplasia
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000028138
Abstract: Abstract Rationale: Fibrous dysplasia is a rare disorder that results in fractures, pain, and disability and can affect any bone in the body. The treatment of symptomatic fibrous dysplasia is determined based on the affected… read more here.
Keywords: denosumab treatment; lesion; treatment; fibrous dysplasia ... See more keywords
AB0827 IS DENOSUMAB SAFE IN HIV PATIENTS?
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.7858
Abstract: Background The survival of the infected patients by the human immunodeficiency virus (HIV) has increased in the last years, increasing the incidental comorbilities, being osteoporosis (OP) one of them, caused by traditional risk factors, by… read more here.
Keywords: hiv patients; treatment; hiv; compliance ... See more keywords
Utility of intraoperative magnetic resonance imaging for giant cell tumor of bone after denosumab treatment: a pilot study.
Sign Up to like & getrecommendations! Published in 2021 at "Acta radiologica"
DOI: 10.1177/0284185121989515
Abstract: BACKGROUND Giant cell tumor of bone (GCTB) is an intermediate but locally aggressive neoplasm. Current treatment of high-risk GCTB involves administration of denosumab, which inhibits bone destruction and promotes osteosclerosis. However, denosumab monotherapy is not… read more here.
Keywords: utility; treatment; residual tumor; denosumab treatment ... See more keywords
Denosumab treatment in the management of patients with advanced prostate cancer: clinical evidence and experience
Sign Up to like & getrecommendations! Published in 2017 at "Therapeutic Advances in Urology"
DOI: 10.1177/1756287216686018
Abstract: Osteoprotective therapies have become an essential component in the management of advanced prostate cancer (PC) patients as bone metastases (BMs) have a major impact on morbidity and mortality. Denosumab is a fully humanized antibody targeting… read more here.
Keywords: denosumab; prostate cancer; management; denosumab treatment ... See more keywords
Tumor Growth Rate in Spinal Giant Cell Tumors of Bone and Association With the Immune Microenvironment and Denosumab Treatment Responsiveness: A Multicenter Study
Sign Up to like & getrecommendations! Published in 2022 at "Neurosurgery"
DOI: 10.1227/neu.0000000000002237
Abstract: BACKGROUND: Currently, little is known about the prognostic value of tumor growth rate (TGR) in spinal giant cell tumors of bone (GCTB). OBJECTIVE: To investigate the correlation of TGR with clinicopathological features, immune microenvironment, prognosis,… read more here.
Keywords: treatment responsiveness; denosumab treatment; tumor; treatment ... See more keywords
Efficacy and safety of denosumab treatment in a prepubertal patient with cherubism
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DOI: 10.1515/jpem-2019-0581
Abstract: Abstract Background Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand, which strongly suppresses osteoclasts. Cherubism is a rare autosomal dominant disorder characterized by symmetrical swelling of the jaws, in which the… read more here.
Keywords: efficacy safety; cherubism; treatment; denosumab ... See more keywords
The Activation of PDGFRβ on Mononuclear Stromal/Tumor Cells in Giant Cell Tumor of Bone After Denosumab Treatment. An Immunohistochemical Study of Five Cases
Sign Up to like & getrecommendations! Published in 2022 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2022.1610633
Abstract: Due to the relatively high recurrence rate and the destructive nature of the tumor, the treatment of giant cell tumor is still a challenge. Denosumab appeared to be a promising candidate as a therapeutic drug.… read more here.
Keywords: denosumab treatment; stromal tumor; tumor cells; treatment ... See more keywords