Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28265-0
Abstract: DENR and MCTS1 have been identified as oncogenes in several different tumor entities. The heterodimeric DENR·MCTS1 protein complex promotes translation of mRNAs containing upstream Open Reading Frames (uORFs). We show here that DENR is phosphorylated… read more here.
Keywords: denr; cell; protein; mitosis ... See more keywords
DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29754-y
Abstract: RNA-binding proteins (RBPs) can recognize thousands of RNAs that help to maintain cell homeostasis, and RBP dysfunction is frequently observed in various cancers. However, whether specific RBPs are involved in tumor immune evasion by regulating… read more here.
Keywords: expression; immune evasion; denr; tumor immune ... See more keywords
High expression of density-regulated re-initiation and release factor drives tumourigenesis and affects clinical outcome
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2018.9620
Abstract: Previously, certain experiments have suggested that density-regulated re-initiation and release factor (DENR) could serve important roles in cancer, however, to the best of our knowledge, a comprehensive analysis of DENR and its association with cancer… read more here.
Keywords: initiation release; denr; density regulated; expression ... See more keywords