LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.07.028
Abstract: Excitatory hilar mossy cells (MCs) in the dentate gyrus receive inputs from dentate granule cells (GCs) and project back to GCs locally, contralaterally, and along the longitudinal axis of the hippocampus, thereby establishing an associative… read more here.
Keywords: ltp; dentate granule; dentate gyrus; inhibition ... See more keywords
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00530-z
Abstract: Congenital hypothyroidism (CH), a common neonatal endocrine disorder, can result in cognitive deficits if delay in diagnose and treatment. Dentate gyrus (DG) is the severely affected subregion of the hippocampus by the CH, where the… read more here.
Keywords: dentate granule; congenital hypothyroidism; dentate; spine growth ... See more keywords
Recruitment of parvalbumin and somatostatin interneuron inputs to adult born dentate granule neurons
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-74385-2
Abstract: GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the functional connectivity between abDGCs and local interneurons is required to understand their development and integration into the hippocampal circuit. We… read more here.
Keywords: adult born; dentate granule; born dentate; parvalbumin somatostatin ... See more keywords
Adult-Generated Dentate Granule Cells in Epilepsy: Loyal Gatekeepers or Evil Changelings?
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsy Currents"
DOI: 10.1177/15357597221145262
Abstract: Adult Born Dentate Granule Cell Mediated Upregulation of Feedback Inhibition in a Mouse Model of Traumatic Brain Injury Kang YJ, Lee SH, Boychuk JA, Butler CR, Juras JA, Cloyd RA, Smith BN. J Neurosci. 2022;42(37):7077-7093.… read more here.
Keywords: dentate granule; dgcs; injury; feedback inhibition ... See more keywords
Early-Age Running Enhances Activity of Adult-Born Dentate Granule Neurons Following Learning in Rats
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0237-17.2017
Abstract: Abstract Cognitive reserve, the brain’s capacity to draw on enriching experiences during youth, is believed to protect against memory loss associated with a decline in hippocampal function, as seen in normal aging and neurodegenerative disease.… read more here.
Keywords: adult born; dentate granule; born dentate; activity adult ... See more keywords
Dentate Granule Cells Recruited in the Home Environment Display Distinctive Properties
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.609123
Abstract: The dentate granule cells (DGCs) play a crucial role in learning and memory. Many studies have described the role and physiological properties of these sparsely active neurons using different behavioral contexts. However, the morpho-functional features… read more here.
Keywords: home; dentate granule; home environment; dgcs ... See more keywords
KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.30935
Abstract: Kinesin super family protein 2A (KIF2A), an ATP-dependent microtubule (MT) destabilizer, regulates cell migration, axon elongation, and pruning in the developing nervous system. KIF2A mutations have recently been identified in patients with malformed cortical development.… read more here.
Keywords: hippocampal wiring; dentate granule; development; postnatal hippocampal ... See more keywords