Localization and pathogenic role of the cysteine protease dentipain in Treponema denticola.
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DOI: 10.1111/omi.12406
Abstract: The Msp protein complex and the serine protease dentilisin are the best-characterized virulence factors in Treponema denticola, the major etiological agent of chronic periodontitis. In addition to these outer sheath factors, the cysteine protease dentipain… read more here.
Keywords: cysteine protease; denticola; treponema denticola; dentipain ... See more keywords
Characterization of Treponema denticola Major Surface Protein (Msp) by Deletion Analysis and Advanced Molecular Modeling
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DOI: 10.1128/jb.00228-22
Abstract: The Treponema denticola gene encoding its major surface protein (Msp) is an ortholog of the T. pallidum tprA to -K gene family that includes tprK, whose remarkable in vivo hypervariability is proposed to contribute to… read more here.
Keywords: pallidum; denticola; surface; treponema ... See more keywords
Identification and Characterization of the Alternative σ28 Factor in Treponema denticola
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00248-22
Abstract: Spirochetes are a group of medically important but understudied bacteria. One of the unique aspects of spirochetes is that they have periplasmic flagella (PF, also known as endoflagella) which give rise to their unique spiral… read more here.
Keywords: denticola; role; treponema denticola; factor ... See more keywords
Treponema denticola Promotes OSCC Development via the TGF-β Signaling Pathway
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DOI: 10.1177/00220345211067401
Abstract: Numerous studies have demonstrated an association between periodontitis and oral squamous cell carcinoma (OSCC), and periodontal pathogens such as Treponema denticola are implicated in the pathogenesis of OSCC. Previous studies have mainly focused on T.… read more here.
Keywords: cell; cell proliferation; denticola; development ... See more keywords
Treponema denticola Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Hippocampal Neuroinflammation in Mice.
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DOI: 10.1177/00220345221076772
Abstract: Alzheimer's disease (AD) is the most common type of dementia. Tau hyperphosphorylation and amyloid β (Aβ) deposition are the key pathological hallmarks of AD. Recent studies have shown that periodontitis is a significant risk factor… read more here.
Keywords: tau; treponema denticola; tau hyperphosphorylation; mice ... See more keywords