Antibiotics Disturb Dentin Formation and Differentiation of Dental Pulp Stem Cells: The Role of Microbiota in Cellular Turnover of Mouse Incisor
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells International"
DOI: 10.1155/2020/5154707
Abstract: Dentin formation was dependent on osteo-/odontogenic differentiation of dental pulp stem cells (DPSCs). It was observed in previous studies that antibiotic treatment in a clinical and animal model resulted in impaired mineralization of dental tissues.… read more here.
Keywords: dentin formation; stem cells; differentiation; microbiota ... See more keywords
Overexpressed Sirt1 in MSCs Promotes Dentin Formation in Bmi1-Deficient Mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Dental Research"
DOI: 10.1177/0022034518781509
Abstract: Sirt1 promotes odontoblastic gene expression in human dental pulp cells, whereas the inhibition of Sirt1 downregulates the expression of those genes. To investigate whether the overexpression of Sirt1 in mesenchymal stem cells (MSCs) driven by… read more here.
Keywords: sirt1; bmi1 deficient; dentin formation; mice ... See more keywords
Loss of IκBζ Drives Dentin Formation via Altered H3K4me3 Status
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221075968
Abstract: Enforced enrichment of the active promoter marks trimethylation of histone H3 lysine 4 (H3K4me3) and acetylation of histone H3 lysine 27 (H3K27ac) by inhibiting histone demethylases and deacetylases is positively associated with hard tissue formation… read more here.
Keywords: status; formation; null mice; dentin ... See more keywords
Vitronectin-Derived Peptide Promotes Reparative Dentin Formation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221101506
Abstract: Exposed dental pulp can maintain its vitality through a pulp-capping procedure with biocompatible materials, followed by reparative dentin formation. Our previous study demonstrated that a vitronectin-derived peptide (VnP-16) promotes osteoblast differentiation and concomitantly restrains osteoclast… read more here.
Keywords: reparative dentin; pulp; dentin; differentiation ... See more keywords
Nuclear factor I-C regulates enamel and dentin formation via the Sonic hedgehog signaling pathway in mouse incisors
Sign Up to like & getrecommendations! Published in 2025 at "BMC Oral Health"
DOI: 10.1186/s12903-025-06276-9
Abstract: Tooth development involves interactions between epithelium and mesenchyme conducted via multiple signaling molecules. This study aimed to investigate the roles of Nuclear factor I-C (NFIC) and Sonic hedgehog (SHH) in regulating enamel and dentin formation… read more here.
Keywords: enamel dentin; mouse incisors; dentin; dentin formation ... See more keywords
Hemicentin-1 is an essential extracellular matrix component during tooth root formation by promoting mesenchymal cells differentiation
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2024.1435241
Abstract: Introduction: Root dentin formation is an important process in tooth development. We tried to identify potential genes that regulate root dentin formation which could be potentially used for the regeneration and repair of defective or… read more here.
Keywords: extracellular matrix; formation; dentin formation; root ... See more keywords
Involvement of M1/M2 Macrophage Polarization in Reparative Dentin Formation
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12111812
Abstract: In cases in which dental pulp tissue is accidentally exposed, direct pulp capping is often performed to induce reparative dentin formation. Although macrophages are essential for the inflammatory response and tissue repair, the emergence pattern… read more here.
Keywords: pulp tissue; dental pulp; reparative dentin; pulp ... See more keywords