Dentoalveolar Defects of Hypophosphatasia are Recapitulated in a Sheep Knock‐In Model
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DOI: 10.1002/jbmr.4666
Abstract: Hypophosphatasia (HPP) is the inherited error‐of‐metabolism caused by mutations in ALPL, reducing the function of tissue‐nonspecific alkaline phosphatase (TNAP/TNALP/TNSALP). HPP is characterized by defective skeletal and dental mineralization and is categorized into several clinical subtypes… read more here.
Keywords: dentoalveolar defects; cementum; knock; bone ... See more keywords