GzESTY as an optimized cell-based assay for initial steps in GPCR deorphanization
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DOI: 10.1038/s41467-025-59850-8
Abstract: G protein-coupled receptors (GPCRs) are key pharmacological targets, yet many remain underutilized due to unknown activation mechanisms and ligands. Orphan GPCRs, lacking identified natural ligands, are a high priority for research, as identifying their ligands… read more here.
Keywords: based assay; cell based; activation; deorphanization ... See more keywords