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Published in 2020 at "Current Protocols in Nucleic Acid Chemistry"
DOI: 10.1002/cpnc.105
Abstract: 6‐Methylpurine (MeP) is a cytotoxic adenine analog that does not exhibit selectivity when administered systemically and could be very useful in a gene therapy approach to cancer treatment involving Escherichia coli purine nucleoside phosphorylase (PNP).…
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Keywords:
deoxy allofuranosyl;
methylpurine;
deoxy;
talofuranosyl methylpurine ... See more keywords
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0
Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00548
Abstract: The bacterial metabolite 1-deoxy-d-xyulose 5-phosphate (DXP) is essential in bacterial central metabolism feeding into isoprenoid, thiamin diphosphate (ThDP), and pyridoxal phosphate de novo biosynthesis. Halting its production through the inhibition of DXP synthase is an…
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Keywords:
mechanism;
synthase;
deoxy;
phosphate ... See more keywords
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2
Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04379
Abstract: An Fe-catalyzed 2-deoxy glycosylation method was developed from 3,4-O-carbonate glycals directly at room temperature. This novel approach enabled facile access to alkyl and aryl 2-deoxy glycosides in high yields with exclusive α-stereoselectivity, tolerating various alcohols,…
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Keywords:
synthesis deoxy;
glycosides via;
deoxy glycosides;
stereoselective synthesis ... See more keywords
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1
Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00632
Abstract: The stereocontrolled synthesis of 2-deoxy-d- arabino-hexopyranosides ("galactopyranosides") using 3,4- O-isopropylidene-6- O- tert-butyldiphenylsilyl-protected glycosyl donors is reported. 2-Deoxy-thioglycoside 3e gives excellent α-selectivity, while galactal 9 leads to, in a two-step protocol, 2-deoxy-β-glycosides in high stereoselectivity. The…
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Keywords:
synthesis deoxy;
deoxy galactopyranosides;
isopropylidene;
deoxy ... See more keywords