Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5′-deoxy-5-fluorocytidine, 5′-deoxy-5-fluorouridine, and 5-fluorouracil
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-019-03837-y
Abstract: PurposeSeveral retrospective studies have shown that the antitumor efficacy of capecitabine-containing chemotherapy decreases when co-administered with a proton pump inhibitor (PPI). Although a reduction in capecitabine absorption by PPIs was proposed as the underlying mechanism,… read more here.
Keywords: deoxy fluorouridine; capecitabine; fluorocytidine deoxy; rabeprazole intake ... See more keywords
Identification of 2′‐deoxy‐2′‐fluorocytidine as a potent inhibitor of Crimean‐Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.10.008
Abstract: Abstract Crimean‐Congo hemorrhagic fever virus (CCHFV), a tick‐borne orthonairovirus, causes a severe hemorrhagic disease in humans (Crimean‐Congo hemorrhagic fever, CCHF). Currently, no vaccines are approved to prevent CCHF; treatment is limited to supportive care and… read more here.
Keywords: reporter; cchfv; virus; identification ... See more keywords