A Diastereoselective Method for the Construction of syn-2'-Deoxy-2'-fluoronucleosides.
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DOI: 10.1021/acs.orglett.2c01561
Abstract: A general and diastereoselective fluorination/glycosylation strategy for the synthesis of 2'-fluorinated nucleosides has been developed. Electrophilic fluorination of a glycal with NFSI provided the 1',2'-difunctionalized furanoside intermediate with high diastereoselectivity. The TBS-protected 2'-deoxyfluorosulfonimide sugar was… read more here.
Keywords: deoxy fluoronucleosides; diastereoselective method; syn deoxy; construction syn ... See more keywords