Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-05053-w
Abstract: To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). Three hundred ninety ALS cases with King’s stages 1, 2, and 3… read more here.
Keywords: fluoro deoxy; deoxy glucose; brain; brain metabolic ... See more keywords
2-Deoxy-D-glucose, not mercaptoacetate, induces a reversible reduction of body temperature in male desert hamsters (Phodopus roborovskii).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thermal biology"
DOI: 10.1016/j.jtherbio.2017.11.011
Abstract: The initiation of torpor is supposed to be related to the availability of metabolic fuels. Studies on metabolic fuel inhibition of glucose by using 2-deoxy-D-glucose (2DG) or fatty acid by mercaptoacetate (MA) in heterothermic mammals… read more here.
Keywords: reduction; desert hamsters; deoxy glucose; desert ... See more keywords
Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00876
Abstract: O-GlcNAc transferase (OGT) catalyzes the installation of N-acetylglucosamine (GlcNAc) O-linked to nucleocytoplasmic proteins (O-GlcNAc) within multicellular eukaryotes. OGT shows surprising tolerance for structural changes in the sugar component of its nucleotide sugar donor substrate, uridine… read more here.
Keywords: glcnac; azido deoxy; glcnac transferase; deoxy glucose ... See more keywords
Synthesis of 2-deoxy-d-glucose coated Fe3O4 nanoparticles for application in targeted delivery of the Pt(iv) prodrug of cisplatin – a novel approach in chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/c9nj05989j
Abstract: A water soluble Pt(IV) prodrug of cisplatin was synthesized by oxidation of cisplatin followed by treatment with succinic anhydride to achieve easily reducible ester linkage at axial positions which was evidenced from cyclic voltammetric analyses.… read more here.
Keywords: cisplatin; formulation; deoxy glucose; prodrug cisplatin ... See more keywords
Glycolytic Inhibitor 2-Deoxy-D-Glucose at Chronic Low Dose Mimics Calorie Restriction in Rats Through Mitohormetic Induction of Reactive Oxygen Species.
Sign Up to like & getrecommendations! Published in 2019 at "Rejuvenation research"
DOI: 10.1089/rej.2018.2125
Abstract: Caloric restriction mimetics (CRMs) provide an exciting antiaging intervention strategy. 2-Deoxy-D-glucose (2-DG), a glycolytic inhibitor, is known to work as a CRM at high doses; however, at chronic high dose it has been linked to… read more here.
Keywords: reactive oxygen; low dose; glycolytic inhibitor; deoxy glucose ... See more keywords
One-Step Conversion to a Disubstituted Cyclopentenone from 2-Deoxy-d-Glucose and Application to Synthesis of Prostaglandin E1 Methyl Ester
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20180241
Abstract: We have developed a facile one-step conversion of 2-deoxy-d-glucose to form a disubstituted cyclopentenone through catalyst-free hydrothermal reaction under mild conditions. The use of 2-deoxy-d-gl... read more here.
Keywords: step conversion; one step; deoxy glucose; disubstituted cyclopentenone ... See more keywords
2-Deoxy-D-glucose and combined 2-Deoxy-D-glucose/albendazole exhibit therapeutic efficacy against Echinococcus granulosus protoscoleces and experimental alveolar echinococcosis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010618
Abstract: 2-Deoxy-D-glucose (2-DG) is a glucose analog used as a promising anticancer agent. It exerts its effects by inhibiting the glycolytic energy metabolism to deplete cells of energy. The larval stage of Echinococcus relies on glycolysis… read more here.
Keywords: deoxy glucose; granulosus protoscoleces; echinococcus granulosus; echinococcus ... See more keywords
Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0217761
Abstract: Regulatory T cells (Tregs) are required for the maintenance of immune tolerance and adoptive Treg infusion therapy has become a promising approach to suppress immune responses in diseases such as autoimmunity and transplant rejection. However,… read more here.
Keywords: deoxy glucose; proliferation; 2dg treatment; expression ... See more keywords
Metformin and 2-Deoxy-d-glucose synergistically inhibit the viability of thyroid papillary carcinoma with BRAF mutation by ROS-dependent PI3K/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230223124733
Abstract: The aim of this study was to explore the molecular mechanism through which metformin combined with 2-deoxy-d-glucose (2-DG) decreases the viability of BCPAP thyroid papillary carcinoma cells. BCPAP cells were treated with only metformin, only… read more here.
Keywords: pi3k akt; thyroid papillary; deoxy glucose; papillary carcinoma ... See more keywords
Utility of flouro-deoxy-glucose positron emission tomography/computed tomography in the diagnostic and staging evaluation of patients with primary CNS lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "CNS Oncology"
DOI: 10.2217/cns-2019-0016
Abstract: Aim: To prospectively assess the clinical utility of pretreatment flouro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with primary central nervous system (CNS) lymphoma (PCNSL). Materials & methods: Patients with suspected/proven PCNSL underwent baseline whole-body… read more here.
Keywords: cns lymphoma; deoxy glucose; glucose positron; flouro deoxy ... See more keywords
2-Deoxy-D-Glucose and its Derivatives for the COVID-19 Treatment: An Update
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.899633
Abstract: Treatment choices for the “severe acute respiratory syndrome‐related coronavirus‐2 (SARS‐CoV‐2)” are inadequate, having no clarity on efficacy and safety profiles. Currently, no established intervention has lowered the mortality rate in the “coronavirus disease 2019 (COVID‐19)”… read more here.
Keywords: covid treatment; derivatives covid; glucose derivatives; deoxy glucose ... See more keywords