Structural, energetics and vibrational analyses of monomeric and dimeric forms of 2-deoxy-2-(3-methyl-3-nitrosourea)-1-D-glucopyranose
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DOI: 10.1016/j.molstruc.2020.129588
Abstract: Abstract The quantum chemical calculations and IR & Raman spectra have been used to characterize the structural, energetics and vibrational properties of 2-deoxy-2-(3-methyl-3-nitrosourea)-1-D-glucopyranose (streptozotocin, STZ), which is widely used in diabetes research. The two conformers… read more here.
Keywords: nitrosourea glucopyranose; structural energetics; monomeric dimeric; energetics vibrational ... See more keywords
Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects
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DOI: 10.1021/jacs.2c01679
Abstract: Although 2′-deoxy-2′-α-F-2′-β-C-methyl (2′-F/Me) uridine nucleoside derivatives are a successful class of antiviral drugs, this modification had not been studied in oligonucleotides. Herein, we demonstrate the facile synthesis of 2′-F/Me-modified pyrimidine phosphoramidites and their subsequent incorporation… read more here.
Keywords: target effects; modification; deoxy methyl; activity ... See more keywords