A Cautious but Optimistic Opinion of Submental Cryolipolysis.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA facial plastic surgery"
DOI: 10.1001/jamafacial.2017.0112
Abstract: The increasing consumer demand for minimally invasive or noninvasive procedures has driven a burgeoning industry of technological advances that cater to this desire. Neck adiposity is an emerging area of interest, driven in large part… read more here.
Keywords: reduction; neck; cryolipolysis; submental cryolipolysis ... See more keywords
Block copolymers containing dextran and deoxycholic acid polyesters. Synthesis, self-assembly and hydrophobic drug encapsulation.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115118
Abstract: New biocompatible amphiphilic block copolymers were prepared using two natural compounds as starting materials, a polysaccharide (dextran) and a bile acid (deoxycholic acid). The copolymers were synthesized by dipolar 1,3-cycloaddition reaction between dextran with azide… read more here.
Keywords: microscopy; block copolymers; encapsulation; hydrophobic drug ... See more keywords
Deoxycholic acid-stimulated macrophage-derived exosomes promote intestinal metaplasia and suppress proliferation in human gastric epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173566
Abstract: The crosstalk between macrophages and gastric epithelial cells has emerged as a player in chronic inflammation during intestinal metaplasia. However, the role of bile acid on this modulation remains to be studied. We hypothesized that… read more here.
Keywords: gastric epithelial; intestinal metaplasia; epithelial cells; metaplasia ... See more keywords
Lesion reduction with intralesional deoxycholic acid in Dercum disease with radiographic evidence
Sign Up to like & getrecommendations! Published in 2021 at "JAAD Case Reports"
DOI: 10.1016/j.jdcr.2021.07.009
Abstract: DCA: deoxycholic acid INTRODUCTION Dercum disease, also known as adiposis dolorosa, is a rare disorder characterized by multiple painful lipomas most often arising in women aged 35 to 50 years. There are currently no approved… read more here.
Keywords: dercum disease; radiographic evidence; intralesional deoxycholic; deoxycholic acid ... See more keywords
Synthesis and antimalarial activity of 3′-trifluoromethylated 1,2,4-trioxolanes and 1,2,4,5-tetraoxane based on deoxycholic acid
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2017.11.008
Abstract: HIGHLIGHTSDeoxycholic acid ozonides were synthesized via the Griesbaum coozonolysis for the first time.Two novel steroidal tetraoxanes were obtained by acid‐catalyzed peroxycondensation.Antimalarial activity was evaluated and potency for related compounds was compared. ABSTRACT A series of… read more here.
Keywords: methyl; deoxycholic acid; antimalarial activity; trifluoromethylated trioxolanes ... See more keywords
Deoxycholic Acid-Conjugated Polyethylenimine for Delivery of Heme Oxygenase-1 Gene in Rat Ischemic Stroke Model.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.07.020
Abstract: An efficient gene carrier to the brain is required for successful gene therapy of ischemic stroke. In this study, deoxycholic acid-conjugated polyethylenimine (DA-PEI) was synthesized and evaluated as a heme oxygenase-1 (HO-1) gene carrier for… read more here.
Keywords: ischemic stroke; polyethylenimine; deoxycholic acid; acid conjugated ... See more keywords
Deoxycholic acid induces gastric intestinal metaplasia by activating STAT3 signaling and disturbing gastric bile acids metabolism and microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2120744
Abstract: ABSTRACT Intestinal metaplasia (IM) is the inevitable precancerous stage to develop intestinal-type gastric cancer (GC). Deoxycholic acid (DCA) is the main bile acid (BA) component of duodenogastric reflux and has shown an increased concentration during… read more here.
Keywords: metabolism; ins gas; deoxycholic acid; dca ... See more keywords
ATX-101 (Deoxycholic Acid Injection) Treatment in Men: Insights From Our Clinical Experience
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DOI: 10.1097/dss.0000000000001306
Abstract: BACKGROUND Excess submental fat (SMF), also called a double chin, is an area of concern for men that can be addressed clinically. ATX-101 (deoxycholic acid injection; Kybella in the United States and Belkyra in Canada,… read more here.
Keywords: treatment; atx 101; deoxycholic acid; acid injection ... See more keywords
Real-World Experience With 100 Consecutive Patients Undergoing Neck Contouring With ATX-101 (Deoxycholic Acid): An Updated Report With A 2-Year Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Dermatologic Surgery"
DOI: 10.1097/dss.0000000000001811
Abstract: BACKGROUND Deoxycholic acid (DCA; ATX-101) injection was approved for the treatment of mild-to-moderate convexity associated with submental fat in 2015. OBJECTIVE To evaluate the experience with DCA injections in a clinical practice setting. MATERIALS AND… read more here.
Keywords: consecutive patients; 100 consecutive; treatment; experience ... See more keywords
Recurrent Xanthelasmas Treated With Intralesional Deoxycholic Acid.
Sign Up to like & getrecommendations! Published in 2019 at "Dermatologic Surgery"
DOI: 10.1097/dss.0000000000001936
Abstract: Xanthelasmas represent the most common form of xanthomas. These superficial lipid deposits present as yellow-orange papules and plaques on the eyelids. Although benign, they can be cosmetically disfiguring and cause psychosocial distress. Xanthomas are usually… read more here.
Keywords: recurrent xanthelasmas; intralesional deoxycholic; treated intralesional; xanthelasmas treated ... See more keywords
ATX-101 (Deoxycholic Acid Injection) Leads to Clinically Meaningful Improvement in Submental Fat: Final Data From CONTOUR.
Sign Up to like & getrecommendations! Published in 2019 at "Dermatologic Surgery"
DOI: 10.1097/dss.0000000000002092
Abstract: BACKGROUND Submental fat (SMF) can negatively affect perceptions of health and attractiveness. The Condition of Submental Fullness and Treatment Outcomes Registry (CONTOUR) was designed to understand SMF treatment in clinical practice. OBJECTIVE To report efficacy,… read more here.
Keywords: submental fat; smf; 101 deoxycholic; treatment ... See more keywords