Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13569
Abstract: Multiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the rate‐limiting enzyme deoxycytidine kinase (dCK)… read more here.
Keywords: dck; deoxycytidine kinase; deoxyribonucleoside salvage; multiple sclerosis ... See more keywords
A Humanized Yeast Phenomic Model of Deoxycytidine Kinase to Predict Genetic Buffering of Nucleoside Analog Cytotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10100770
Abstract: Knowledge about synthetic lethality can be applied to enhance the efficacy of anticancer therapies in individual patients harboring genetic alterations in their cancer that specifically render it vulnerable. We investigated the potential for high-resolution phenomic… read more here.
Keywords: ontology; yeast phenomic; gene; deoxycytidine kinase ... See more keywords