Synthesis of N2‐Aryl‐2′‐Deoxyguanosine Modified Phosphoramidites and Oligonucleotides
Sign Up to like & getrecommendations! Published in 2019 at "Current Protocols in Nucleic Acid Chemistry"
DOI: 10.1002/cpnc.93
Abstract: The N2‐position of 2′‐deoxyguanosine (N2‐position in dG) is well known for forming carcinogenic minor groove DNA adducts, which originate from environmental pollutants, chemicals, and tobacco smoke. The N2‐dG DNA adducts have strong implications on biological… read more here.
Keywords: modified phosphoramidites; dna; synthesis; deoxyguanosine ... See more keywords
Antioxidant defense system versus 8-hydroxy-2’-deoxyguanosine; a short look to recent findings
Sign Up to like & getrecommendations! Published in 2018 at "Journal of renal injury prevention"
DOI: 10.15171/jrip.2018.29
Abstract: Implication for health policy/practice/research/medical education: The impact of 8-hydroxy-2’ -deoxyguanosine as an oxidative stress biomarker has been detected in many diseases, including bladder and prostate cancer, rheumatoid arthritis and renal disease. Please cite this paper… read more here.
Keywords: system versus; hydroxy deoxyguanosine; deoxyguanosine; antioxidant defense ... See more keywords
Bacterial 2′-Deoxyguanosine Riboswitch Classes as Potential Targets for Antibiotics: A Structure and Dynamics Study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23041925
Abstract: The spread of antibiotic-resistant bacteria represents a substantial health threat. Current antibiotics act on a few metabolic pathways, facilitating resistance. Consequently, novel regulatory inhibition mechanisms are necessary. Riboswitches represent promising targets for antibacterial drugs. Purine… read more here.
Keywords: structure dynamics; bacterial deoxyguanosine; deoxyguanosine; deoxyguanosine riboswitch ... See more keywords
8-Oxo-7,8-Dihydro-2′-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25010202
Abstract: The growing clinical and epidemiological significance of gestational diabetes mellitus results from its constantly increasing worldwide prevalence, obesity, and overall unhealthy lifestyle among women of childbearing age. Oxidative stress seems to be the most important… read more here.
Keywords: gestational diabetes; oxo dihydro; deoxyguanosine; dihydro deoxyguanosine ... See more keywords