Development of an activity assay for characterizing deoxyhypusine synthase and its diverse reaction products
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DOI: 10.1002/2211-5463.13046
Abstract: Deoxyhypusine synthase transfers an aminobutyl moiety from spermidine to the eukaryotic translation initiation factor 5A (eIF5A) in the first step of eIF5A activation. This exclusive post‐translational modification is conserved in all eukaryotes. Activated eIF5A has… read more here.
Keywords: development activity; deoxyhypusine synthase; reaction; synthase ... See more keywords
Homospermidine biosynthesis in the cyanobacterium Anabaena requires a deoxyhypusine synthase homologue and is essential for normal diazotrophic growth
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DOI: 10.1111/mmi.14006
Abstract: Polyamines are primordial, small organic polycations present in almost all cells, but their roles in bacteria are poorly understood. sym‐Homospermidine is the dominant polyamine in the filamentous, N2‐fixing, heterocyst‐forming cyanobacterium Anabaena sp. PCC 7120. Synthesis… read more here.
Keywords: diazotrophic growth; deoxyhypusine synthase; growth; synthase homologue ... See more keywords
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major
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DOI: 10.1371/journal.pntd.0008762
Abstract: Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell… read more here.
Keywords: leishmania major; malayi leishmania; deoxyhypusine synthase; target ... See more keywords
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase
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DOI: 10.2210/pdb6p4v/pdb
Abstract: Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for... read more here.
Keywords: discovery novel; novel allosteric; inhibitors deoxyhypusine; allosteric inhibitors ... See more keywords
Half Way to Hypusine—Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase
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DOI: 10.3390/biom10040522
Abstract: Deoxyhypusine synthase (DHS) is a transferase enabling the formation of deoxyhypusine, which is the first, rate-limiting step of a unique post-translational modification: hypusination. DHS catalyses the transfer of a 4-aminobutyl moiety of polyamine spermidine to… read more here.
Keywords: deoxyhypusine synthase; dhs; substrate; substrate recognition ... See more keywords