A randomized, phase 2 study of deoxyuridine triphosphatase inhibitor, TAS-114, in combination with S-1 versus S-1 alone in patients with advanced non-small-cell lung cancer
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DOI: 10.1007/s10637-020-00930-5
Abstract: Introduction TAS-114 is a potent inhibitor of deoxyuridine triphosphatase, which is a gatekeeper protein preventing uracil and 5-fluorouracil (5-FU) misincorporation into DNA. TAS-114 has been suggested to enhance the antitumor activity of 5-FU. This randomized,… read more here.
Keywords: group; randomized phase; non small; phase study ... See more keywords
ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase.
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DOI: 10.1021/acs.bioconjchem.8b00124
Abstract: Nucleotide surveillance enzymes play important roles in human health, by monitoring damaged monomers in the nucleotide pool and deactivating them before they are incorporated into chromosomal DNA or disrupt nucleotide metabolism. In particular, deamination of… read more here.
Keywords: luminescence; atp linked; deoxyuridine triphosphatase; deoxyuridine ... See more keywords