Protein depalmitoylases
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DOI: 10.1080/10409238.2017.1409191
Abstract: Abstract Protein depalmitoylation describes the removal of thioester-linked long chain fatty acids from cysteine residues in proteins. For many S-palmitoylated proteins, this process is promoted by acyl protein thioesterase enzymes, which catalyze thioester hydrolysis to… read more here.
Keywords: protein; protein depalmitoylases; protein thioesterase; depalmitoylation ... See more keywords
Wogonoside induces depalmitoylation and translocation of PLSCR1 and N‐RAS in primary acute myeloid leukaemia cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13481
Abstract: Acute myeloid leukaemia (AML) comprises a range of disparate genetic subtypes, involving complex gene mutations and specific molecular alterations. Post‐translational modifications of specific proteins influence their translocation, stability, aggregation and even leading disease progression. Therapies… read more here.
Keywords: myeloid leukaemia; translocation plscr1; translocation; plscr1 ... See more keywords
Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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DOI: 10.1371/journal.pbio.3001590
Abstract: Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation on molecular dissection of disease… read more here.
Keywords: palmitoyl protein; ppt1; protein thioesterase; disulfide bond ... See more keywords