The role of dePARylation in DNA damage repair and cancer suppression.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.02.002
Abstract: Poly(ADP-ribosyl)ation (PARylation) is a reversible post-translational modification regulating various biological pathways including DNA damage repair (DDR). Rapid turnover of PARylation is critically important for an optimal DNA damage response and maintaining genomic stability. Recent studies… read more here.
Keywords: dna damage; damage repair; deparylation; role ... See more keywords
Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav4340
Abstract: A novel PARG inhibitor traps DNA repair factors at DNA lesions and selectively kills tumor cells with DNA repair defects. While poly(ADP-ribosyl)ation (PARylation) plays an important role in DNA repair, the role of dePARylation in… read more here.
Keywords: inhibitor; dna repair; deparylation; cancer ... See more keywords